Caspases: A treatment target for neurodegenerative disease?

被引：51

作者：

Holtzman, DM ^{[1
]}

Deshmukh, M ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT MOL BIOL & PHARMACOL,ST LOUIS,MO 63110

来源：

NATURE MEDICINE | 1997年 / 3卷 / 09期

关键词：

D O I：

10.1038/nm0997-954

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treating neurodegenerative disease with drugs that inhibit the activity of caspases (proteases that regulate apoptosis) is a therapeutic avenue beginning to be explored.

引用

页码：954 / 955

页数：2

共 14 条

[1] Programmed cell death in neurons: Focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons [J].

Deshmukh, M ;

Johnson, EM .

MOLECULAR PHARMACOLOGY, 1997, 51 (06) :897-906

[2] GENETIC-CONTROL OF PROGRAMMED CELL-DEATH IN THE NEMATODE C-ELEGANS [J].

ELLIS, HM ;

HORVITZ, HR .

CELL, 1986, 44 (06) :817-829

[3] Inhibition of ICE slows ALS in mice [J].

Friedlander, RM ;

Brown, RH ;

Gagliardini, V ;

Wang, J ;

Yuan, JY .

NATURE, 1997, 388 (6637) :31-31

[4] Inhibition of interleukin 1 beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage [J].

Hara, H ;

Friedlander, RM ;

Gagliardini, V ;

Ayata, C ;

Fink, K ;

Huang, ZH ;

ShimizuSasamata, M ;

Yuan, JY ;

Moskowitz, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :2007-2012

[5] Neuronal death in developmental models: Possible implications in neuropathology [J].

Johnson, EM ;

Deckwerth, TL ;

Deshmukh, M .

BRAIN PATHOLOGY, 1996, 6 (04) :397-409

[6] APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS [J].

KERR, JFR ;

WYLLIE, AH ;

CURRIE, AR .

BRITISH JOURNAL OF CANCER, 1972, 26 (04) :239-+

[7] Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease [J].

Kim, TW ;

Pettingell, WH ;

Jung, YK ;

Kovacs, DM ;

Tanzi, RE .

SCIENCE, 1997, 277 (5324) :373-376

[8] Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis [J].

Kostic, V ;

JacksonLewis, V ;

deBilbao, F ;

DuboisDauphin, M ;

Przedborski, S .

SCIENCE, 1997, 277 (5325) :559-562

[9] Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice [J].

Kuida, K ;

Zheng, TS ;

Na, SQ ;

Kuan, CY ;

Yang, D ;

Karasuyama, H ;

Rakic, P ;

Flavell, RA .

NATURE, 1996, 384 (6607) :368-372

[10] PEPTIDE INHIBITORS OF THE ICE PROTEASE FAMILY ARREST PROGRAMMED CELL-DEATH OF MOTONEURONS IN-VIVO AND IN-VITRO [J].

MILLIGAN, CE ;

PREVETTE, D ;

YAGINUMA, H ;

HOMMA, S ;

CARDWELL, C ;

FRITZ, LC ;

TOMASELLI, KJ ;

OPPENHEIM, RW ;

SCHWARTZ, LM .

NEURON, 1995, 15 (02) :385-393

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