Cation-Chloride Cotransporters and Neuronal Function

被引:602
作者
Blaesse, Peter [1 ]
Airaksinen, Matti S. [2 ]
Rivera, Claudio [3 ]
Kaila, Kai [1 ,2 ]
机构
[1] Univ Helsinki, Dept Biol & Environm Sci, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Ctr Neurosci, FIN-00014 Helsinki, Finland
[3] Univ Helsinki, Inst Biotechnol, FIN-00014 Helsinki, Finland
基金
芬兰科学院;
关键词
K-CL COTRANSPORTER; RAT NEOCORTICAL NEURONS; TEMPORAL-LOBE EPILEPSY; SECRETORY NA+-K+-2CL(-) COTRANSPORTER; DEVELOPMENTAL UP-REGULATION; REDUCED SEIZURE THRESHOLD; FOCAL CEREBRAL-ISCHEMIA; HIPPOCAMPAL AREA CA3; AUDITORY BRAIN-STEM; INTRACELLULAR CHLORIDE;
D O I
10.1016/j.neuron.2009.03.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent years have witnessed a steep increase in studies on the diverse roles of neuronal cation-chloride co-transporters (CCCs). The versatility of CCC gene transcription, posttranslational modification, and trafficking are on par with what is known about ion channels. The cell-specific and subcellular expression patterns of different CCC isoforms have a key role in modifying a neuron's electrophysiological phenotype during development, synaptic plasticity, and disease. While having a major role in controlling responses mediated by GABA(A) and glycine receptors, CCCs also show close interactions with glutamatergic signaling. A crosstalk among CCCs and trophic factors is important in short-term and long-term modification of neuronal properties. CCCs appear to be multifunctional proteins that are also involved in shaping neuronal structure at various stages of development, from stem cells to synaptogenesis. The rapidly expanding work on CCCs promotes our understanding of fundamental mechanisms that control brain development and functions under normal and pathophysiological conditions.
引用
收藏
页码:820 / 838
页数:19
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