Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom

被引：115

作者：

Pedersen, OS ^{[1
]}

Pedersen, EB ^{[1
]}

机构：

[1] Odense Univ, Dept Chem, DK-5230 Odense M, Denmark

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1999年 / 10卷 / 06期

关键词：

HIV-1; non-nucleoside reverse transcriptase inhibitors; HEPT; nevirapine; delavirdine; efavirenz; trovirdine;

D O I：

10.1177/095632029901000601

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside reverse transcriptase (RT) inhibitors and protease inhibitors. The first generation of NNRTIs have, however, suffered from the rapid development of resistance. This review discusses the properties of the FDA-approved NNRTI drugs and focuses on the recent efforts being made to produce second generation inhibitors that circumvent this resistance problem.

引用

页码：285 / 314

页数：30

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