Leishmania commandeers the host inflammatory response through neutrophils

被引：14

作者：

Jochim, Ryan C. ^{[1
]}

Teixeira, Clarissa ^{[1
]}

机构：

[1] NIAID, Vector Mol Biol Unit, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA

来源：

TRENDS IN PARASITOLOGY | 2009年 / 25卷 / 04期

关键词：

T-CELL-ACTIVATION; CUTANEOUS LEISHMANIASIS; INTRACELLULAR SURVIVAL; PROMASTIGOTES; DONOVANI; GRANULOCYTES; ATTACHMENT; IL-1-ALPHA; IL-1-BETA; MICROBES;

D O I：

10.1016/j.pt.2009.01.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Neutrophils are the first cells to migrate to the site of tissue damage. Recent work has addressed Leishmania survival and entry into macrophages through the infection of neutrophils that are recruited as a normal response to sandfly bites. New findings indicate that Leishmania is able to escape from neutrophils and 'silently' enter macrophages, a modification of the 'Trojan horse' model. Neutrophil depletion impaired disease progression, indicating an important role for neutrophils in leishmaniasis.

引用

页码：145 / 147

页数：3

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