Mesenchymal Stem Cells in the Induction of Transplantation Tolerance

被引：19

作者：

Bartholomew, Amelia ^{[1
]}

Polchert, David ^{[1
]}

Szilagyi, Erzsebet ^{[1
]}

Douglas, G. W. ^{[1
]}

Kenyon, Norma ^{[2
]}

机构：

[1] Univ Illinois, Dept Surg, Chicago, IL 60612 USA

[2] Univ Milan, Miller Sch Med, Diabet Res Inst, Miami, FL USA

来源：

TRANSPLANTATION | 2009年 / 87卷 / 09期

关键词：

Tolerance; Mesenchymal stem cells; Transplantation; MARROW STROMAL CELLS; MURINE BONE-MARROW; LYMPHOCYTE-PROLIFERATION; IN-VITRO; INHIBIT; RESPONSES; CULTURE; GAMMA;

D O I：

10.1097/TP.0b013e3181a287e6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mesenchymal stem cells directly suppress ongoing immune responses. Through production of toleragenic cytokines, inhibition of lymphocyte proliferation, delivery of reparative and protective signals after reperfusion injury, and facilitation of hematopoietic chimerism, these cells demonstrate a wide-ranging potential for the development of multifaceted toleragenic strategies after transplantation.

引用

页码：S55 / S57

页数：3

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