Synonymous codon bias is related to gene length in Escherichia coli: Selection for translational accuracy?

被引:187
作者
EyreWalker, A [1 ]
机构
[1] RUTGERS STATE UNIV,DEPT BIOL SCI,PISCATAWAY,NJ 08855
关键词
Escherichia coli; synonymous codon bias; translation; accuracy;
D O I
10.1093/oxfordjournals.molbev.a025646
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The level of synonymous codon bias is shown to be positively correlated to gene length in Escherichia coli genes which are thought to be expressed at similar levels; these are genes whose products are present in multimeric proteins in equimolar amounts. It is argued that the positive correlation could be caused by selection to avoid missense errors during translation. Since the cost of producing a protein is proportional to its length, selection in favor of codons which increase accuracy should be greater in longer genes, and long genes should therefore have higher synonymous codon bias. It is also shown that there is variation in synonymous codon use which is independent of either expression level, gene length, amino acid composition, or chromosomal location. This variation is consistent with selection for translational accuracy but may have other origins.
引用
收藏
页码:864 / 872
页数:9
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