Preparation of porous calcium phosphates using a ceramic foaming technique combined with a hydrothermal treatment and the cell response with incorporation of osteoblast-like cells

被引:8
作者
Aoki, S
Yamaguchi, S
Nakahira, A
Suganuma, K
机构
[1] Osaka Univ, Inst Sci Ind Res, Ibaraki, Osaka 5670047, Japan
[2] Kyoto Inst Technol, Sakyo Ku, Kyoto 6068585, Japan
关键词
porous calcium phosphates; ceramic foaming technique; hydrothermal treatment; surface roughness; MC3T3-El cells;
D O I
10.2109/jcersj.112.193
中图分类号
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号
0805 [材料科学与工程]; 080502 [材料学];
摘要
Four porous calcium phosphates (HAp, HAp/beta-TCP, beta-TCP, and alpha-TCP) were prepared using a ceramic foaming technique combined with a hydrothermal treatment. These porous calcium phosphates had enough pore size, high specific surface area, and high porosity (>80%) for the cell growth of osteoblast-like cells. The compositions of the porous calcium phosphates depended on the solution in hydrothermal treatment and the sintering temperature. The cell activities of MC3T3-E1 cells on porous HAp, HAp/beta-TCP, and beta-TCP were similar to that of monolayer cultivation as a control in MTT assay, ALPase activities, and the cell density.
引用
收藏
页码:193 / 199
页数:7
相关论文
共 53 条
[1]
AIBA S, 1987, CERAM SOC JAPAN, P3
[2]
BARRALET J, 1994, J MATER SCI-MATER M, V5, P154
[3]
Osteoblast-mediated mineral deposition in culture is dependent on surface microtopography [J].
Boyan, BD ;
Bonewald, LF ;
Paschalis, EP ;
Lohmann, CH ;
Rosser, J ;
Cochran, DL ;
Dean, DD ;
Schwartz, Z ;
Boskey, AL .
CALCIFIED TISSUE INTERNATIONAL, 2002, 71 (06) :519-529
[4]
DACULSI G, 1990, BIOMATERIALS, V11, P86
[5]
BONE-GRAFT AND BONE-GRAFT SUBSTITUTES - A REVIEW OF CURRENT TECHNOLOGY AND APPLICATIONS [J].
DAMIEN, CJ ;
PARSONS, JR .
JOURNAL OF APPLIED BIOMATERIALS, 1991, 2 (03) :187-208
[6]
BIOCERAMICS CONSISTING OF CALCIUM-PHOSPHATE SALTS [J].
DEGROOT, K .
BIOMATERIALS, 1980, 1 (01) :47-50
[7]
A new method to produce macropores in calcium phosphate cements [J].
del Real, RP ;
Wolke, JGC ;
Vallet-Regí, M ;
Jansen, JA .
BIOMATERIALS, 2002, 23 (17) :3673-3680
[8]
Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength [J].
Deligianni, DD ;
Katsala, ND ;
Koutsoukos, PG ;
Missirlis, YF .
BIOMATERIALS, 2001, 22 (01) :87-96
[9]
Doi Y, 1999, J BIOMED MATER RES, V47, P424, DOI 10.1002/(SICI)1097-4636(19991205)47:3<424::AID-JBM19>3.0.CO
[10]
2-0