Lipid peroxidation induced by ultrasonication in Ehrlich ascitic tumor cells

被引：48

作者：

Hristov, PK

Petrov, LA

Russanov, EM

机构：

[1] Institute of Physiology, Bulgar. Acad. Sci., Acad. G. B., Sofia

来源：

CANCER LETTERS | 1997年 / 121卷 / 01期

关键词：

lipid peroxidation; ultrasound; tumor; free-radicals;

D O I：

10.1016/S0304-3835(97)00318-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The mechanism of sonodynamic action in tumor cells is poorly investigated. It is known that ultrasound generates free radicals in phosphatidylcholine liposomes used as a membrane model. The participation of lipid peroxidation products in the mechanisms of physiological suppression of cell multiplication has been investigated for some tumor cells. In the present work ultrasound-induced lipid peroxidation in Ehrlich ascitic tumor cells was studied. Ultrasonication increased the level of lipid peroxidation quantified by the TBARS method in homogenates from Ehrlich ascitic tumor cells. Changes in the fatty acid composition of lipids from Ehrlich ascitic tumor cells irradiated by sonication were observed. TBARS production obtained by ultrasound was compared to TBARS production obtained by widely used chemical inductors. The free-radical processes evoked by ultrasound are of interest in antitumor therapy. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：7 / 10

页数：4

共 21 条

[1]

POLY-UNSATURATED FATTY ACID-INDUCED CYTO-TOXICITY AGAINST TUMOR-CELLS AND ITS RELATIONSHIP TO LIPID-PEROXIDATION [J].