Innate and acquired resistance to amebiasis in Bangladeshi children

被引:92
作者
Haque, R
Duggal, P
Ali, IM
Hossain, MB
Mondal, D
Sack, RB
Farr, BM
Beaty, TH
Petri, WA
机构
[1] Univ Virginia, Div Infect Dis, Dept Med, Charlottesville, VA 22908 USA
[2] Univ Virginia, Dept Microbiol, Div Infect Dis, Charlottesville, VA 22908 USA
[3] Univ Virginia, Dept Pathol, Div Infect Dis, Charlottesville, VA 22903 USA
[4] Int Ctr Diarrhoeal Dis Res, Ctr Hlth & Populat Res, Dhaka 1000, Bangladesh
[5] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[6] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA
关键词
D O I
10.1086/341566
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Entamoeba histolytica infection and colitis occurred in 55% and 4%, respectively, of a cohort of Bangladeshi preschool children observed for 2 years. DNA typing demonstrated that infecting E. histolytica isolates were genetically diverse. Innate resistance to infection in children was linked to the absence of serum anti-trophozoite IgG. Most children who lacked serum anti-trophozoite IgG failed to develop it in response to a new infection. The serum anti-trophozoite IgG response clustered in families, which is consistent with genetic inheritance. Acquired resistance to infection was linked to intestinal IgA against the carbohydrate-recognition domain of the E. histolytica galactose N-acetyl-D-galactosamine lectin. This was associated with an 86% reduction in new infection over 1 year. Amebiasis is a common and potentially serious infection in children from Dhaka, and both innate and acquired immune responses limit infection.
引用
收藏
页码:547 / 552
页数:6
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