Biological variation responses in fMLP-OMe analogs, introducing bulky protecting groups on the side-chain of hydrophilic residues at position 2

被引:8
作者
Cavicchioni, G
Turchetti, M
Spisani, S
机构
[1] Univ Ferrara, Dept Pharmaceut Sci, I-44100 Ferrara, Italy
[2] Univ Ferrara, Dept Biochem & Mol Biol, I-44100 Ferrara, Italy
来源
JOURNAL OF PEPTIDE RESEARCH | 2002年 / 60卷 / 04期
关键词
chemotaxis; human neutrophils; lysozyme release; N-formylmethionyl peptides; superoxide anion generation;
D O I
10.1034/j.1399-3011.2002.21019.x
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
for-Met-Ser(Bzl)-Phe-OMe, for-Met-Cys(Bzl)-Phe-OMe, for-Met-Tyr(Bzl)-Phe-OMe and for-Met-Lys(Z)-Phe-OMe were synthesized to investigate the importance of a bulky protecting group on the side-chain of a hydrophilic residue at position 2 on the biological activities of human neutrophils. Our results indicate that these compounds do not trigger a good chemotactic response, which, in any case, is not improved with respect to that induced by the analogs with the unprotected residues. Instead, both superoxide anion production and, particularly, lysozyme release are more efficient.
引用
收藏
页码:223 / 231
页数:9
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