New Nitrogen-Containing Sesquiterpenoids from the Taiwanese Soft Coral Cespitularia taeniata MAY

被引：30

作者：

Cheng, Yuan-Bin ^{[1
,2
]}

Chen, Ching-Yeu ^{[3
]}

Kuo, Yao-Haur ^{[4
]}

Shen, Ya-Ching ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 100, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[3] Tzu Hui Inst Technol, Ctr Gen Educ, Pingtung 926, Taiwan

[4] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

CHEMISTRY & BIODIVERSITY | 2009年 / 6卷 / 08期

关键词：

HYPOTENTACULATA; DITERPENES; NORDITERPENOIDS; XENIIDAE;

D O I：

10.1002/cbdv.200800195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Chemical investigation of the EtOH extract of the soft coral Cespitularia taeniata MAY collected in Taiwan has resulted in the isolation of two new sesquiterpene lactams, taenialactams A and B (I and 2, resp.), and a new sesquiterpene lactone. taenialactone A (3), together with 8 beta-methoxyatractylenolide (4) and atractylenolactam (5). The structures of these compounds were determined on the basis of spectroscopic analyses. The in vitro cytotoxic activities of the isolated metabolites were tested against KB, Daoy, and WiDr cell lines. A biogenetic pathway for these novel compounds was proposed.

引用

收藏

页码：1266 / 1272

页数：7

相关论文

共 15 条

[1]

STUDIES OF AUSTRALIAN SOFT CORALS .8. CHEMICAL AND CRYSTALLOGRAPHIC STUDY OF A NOVEL BICYCLIC DITERPENE ALCOHOL WITH A REARRANGED SKELETON FROM AN UNKNOWN SPECIES OF SOFT CORAL [J].

BOWDEN, BF ;

COLL, JC ;

MITCHELL, SJ ;

STOKIE, GJ ;

BLOUNT, JF .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1978, 31 (09) :2039-2047

[2]

STUDIES OF AUSTRALIAN SOFT CORALS .38. STRUCTURE DETERMINATION OF SEVERAL DITERPENES DERIVED FROM A CESPITULARIA SPECIES (COELENTERATA, OCTOCORALLIA, XENIIDAE) [J].

BOWDEN, BF ;

COLL, JC ;

GULBIS, JM ;

MACKAY, MF ;

WILLIS, RH .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1986, 39 (05) :803-812

[3]

STUDIES OF AUSTRALIAN SOFT CORALS .20. A NEW SESQUITERPENE FURAN FROM SOFT CORALS OF THE FAMILY XENIIDAE AND AN EXAMINATION OF CLAVULARIA-INFLATA FROM NORTH QUEENSLAND WATERS [J].

BOWDEN, BF ;

BRAEKMAN, JC ;

COLL, JC ;

MITCHELL, SJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1980, 33 (04) :927-932

[4]

STUDIES OF AUSTRALIAN SOFT CORALS .30. A NOVEL TRISNORSESQUITERPENE FROM A CESPITULARIA SPECIES AND THE ISOLATION OF GUAIAZULENE FROM A SMALL BLUE ALCYONIUM SPECIES [J].

BOWDEN, BF ;

COLL, JC ;

TAPIOLAS, DM .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, 36 (01) :211-214

[5]

2 CEMBRANES FROM CESPITULARIA SPECIES (SOFT CORAL) [J].

BURNS, KP ;

KAZLAUSKAS, R ;

MURPHY, PT ;

WELLS, RJ ;

SCHONHOLZER, P .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1982, 35 (01) :85-94

[6]

APPLICATIONS OF ARTIFICIAL INTELLIGENCE FOR CHEMICAL INFERENCE .21. CHEMICAL STUDIES OF MARINE-INVERTEBRATES .17. COMPUTER-ASSISTED IDENTIFICATION OF [+]-PALUSTROL IN MARINE ORGANISM CESPITULARIA SP, AFF SUBVIRIDIS [J].

CHEER, CJ ;

SMITH, DH ;

DJERASSI, C ;

TURSCH, B ;

BRAEKMAN, JC ;

DALOZE, D .

TETRAHEDRON, 1976, 32 (14) :1807-1810

[7]

A sesquiterpene lactam from Artractylodes macrocephala [J].

Chen, ZL ;

Cao, WY ;

Zhou, GX ;

Wichtl, M .

PHYTOCHEMISTRY, 1997, 45 (04) :765-767

[8]

Diterpenoids, norditerpenoids, and secosteroids from the Formosan soft coral Cespitularia hypotentaculata [J].

Duh, Chang-Yih ;

Li, Chia-Hua ;

Wang, Shang-Kwei ;

Dai, Chang-Feng .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (08) :1188-1192

[9]

Novel terpenoids from the Formosan soft coral Cespitularia hypotentaculata [J].

Duh, CY ;

El-Gamal, AAH ;

Wang, SK ;

Dai, CF .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (10) :1429-1433

[10]

A NEW CARYOPHYLLENE-BASED DITERPENE FROM THE SOFT CORAL, CESPITULARIA SP [J].

KONIG, GM ;

WRIGHT, AD .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (12) :2198-2200