Hypoxia suppresses BCR/Abl and selects imatinib-insensitive progenitors within clonal CML population

被引:59
作者
Giuntoli, S. [1 ]
Rovida, E. [1 ]
Barbetti, V. [1 ]
Cipolleschi, M. G. [1 ]
Olivotto, M. [1 ]
Dello Sbarba, P. [1 ]
机构
[1] Univ Florence, Dipartimento Patol & Oncol Sperimentali, Florence, Italy
关键词
D O I
10.1038/sj.leu.2404224
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1291 / 1293
页数:3
相关论文
共 8 条
[1]  
CIPOLLESCHI MG, 1993, BLOOD, V82, P2031
[2]   The expansion of murine bone marrow cells preincubated in hypoxia as an in vitro indicator of their marrow-repopulating ability [J].
Cipolleschi, MG ;
Rovida, E ;
Ivanovic, Z ;
Praloran, V ;
Olivotto, M ;
Dello Sbarba, P .
LEUKEMIA, 2000, 14 (04) :735-739
[3]   Overproduction of BCR-ABL induces apoptosis in imatinib mesylate-resistant cell lines [J].
Desplat, V ;
Belloc, F ;
Lagarde, V ;
Boyer, C ;
Melo, JV ;
Reiffers, J ;
Praloran, V ;
Mahon, FX .
CANCER, 2005, 103 (01) :102-110
[4]   Punish the parent not the progeny [J].
Elrick, LJ ;
Jorgensen, HG ;
Mountford, JC ;
Holyoake, TL .
BLOOD, 2005, 105 (05) :1862-1866
[5]   Hypoxia maintains and interleukin-3 reduces the pre-colony-forming cell potential of dividing CD34+ murine bone marrow cells [J].
Ivanovic, Z ;
Belloc, F ;
Faucher, JL ;
Cipolleschi, MG ;
Praloran, V ;
Dello Sbarba, P .
EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :67-73
[6]   Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML [J].
Jamieson, CHM ;
Ailles, LE ;
Dylla, SJ ;
Muijtjens, M ;
Jones, C ;
Zehnder, JL ;
Gotlib, J ;
Li, K ;
Manz, MG ;
Keating, A ;
Sawyers, CL ;
Weissman, IL .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (07) :657-667
[7]   Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo [J].
Jiang, XY ;
Ng, E ;
Yip, C ;
Eisterer, W ;
Chalandon, Y ;
Stuible, M ;
Eaves, A ;
Eaves, CJ .
BLOOD, 2002, 100 (10) :3731-3740
[8]   Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines [J].
Weisberg, E ;
Griffin, JD .
BLOOD, 2000, 95 (11) :3498-3505