Pd(O2CCF3)2/Benzoquinone: A Versatile Catalyst System for the Decarboxylative Olefination of Arene Carboxylic Acids

被引：150

作者：

Hu, Peng ^{[1
]}

Kan, Jian ^{[1
]}

Su, Weiping ^{[1
]}

Hong, Maochun ^{[1
]}

机构：

[1] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 11期

关键词：

ELECTRON-RICH OLEFINS; HECK REACTION; ARYL CHLORIDES; COUPLING REACTIONS; VINYL ETHERS; PALLADIUM; ARYLATION; FUNCTIONALIZATION; ACTIVATION; BIARYLS;

D O I：

10.1021/ol9007553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile palladium catalyst system was developed to effect the decarboxylative Heck coupling of a variety of arenecarboxylic acids with a wide range of olefins. The key to obtaining the efficient catalyst system is the use of 1-adamatanecarboxylic acid as additive. Alkyl-substituted olefins with coordinating groups were observed to provide significantly improved regioselectivity compared with other alkyl-substituted olefins lacking coordinating groups, and the acetate group of allylic ester was also tolerated in this reaction.

引用

页码：2341 / 2344

页数：4

共 60 条

[1] New approaches for decarboxylative biaryl coupling [J].