Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia

被引：167

作者：

Nguyen, Hoang ^{[1
]}

Merrill, Bradley J. ^{[1
]}

Polak, Lisa ^{[1
]}

Nikolova, Maria ^{[1
]}

Rendl, Michael ^{[1
]}

Shaver, Timothy M. ^{[2
,3
]}

Pasolli, H. Amalia ^{[1
]}

Fuchs, Elaine ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, Lab Mammalian Cell Biol & Dev, New York, NY 10021 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Stem Cell & Regenerat Med Ctr, Houston, TX 77030 USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 10期

基金：

美国国家卫生研究院;

关键词：

HAIR FOLLICLE MORPHOGENESIS; BETA-CATENIN; STEM-CELLS; TRANSIENT ACTIVATION; MOUSE EPIDERMIS; SELF-RENEWAL; DIFFERENTIATION; MAINTENANCE; REGULATOR; TRIGGER;

D O I：

10.1038/ng.431

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Single-layered embryonic skin either stratifies to form epidermis or responds to Wnt signaling (stabilized beta-catenin) to form hair follicles. Postnatally, stem cells continue to differentially use Wnt signaling in long-term tissue homeostasis. We have discovered that embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors. Using loss-of-function studies and transcriptional analyses, we uncovered consequences to the absence of Tcf3 and Tcf4 in skin that only partially overlap with those caused by beta-catenin deficiency. We established roles for Tcf3 and Tcf4 in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that Tcf proteins have both Wnt-dependent and Wnt-independent roles in lineage determination.

引用

页码：1068 / U38

页数：9

共 32 条

[1] Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT [J].