Involvement of retinoblastoma protein in p27Kip1-induced apoptosis

被引：11

作者：

Oh, S

Kim, TK

Hwang, DS

Yim, J ^{[1
]}

机构：

[1] Seoul Natl Univ, Natl Creat Res Inst Ctr Genet Reprogramming, Inst Mol Biol & Genet, Seoul 151742, South Korea

[2] Seoul Natl Univ, Dept Microbiol, Seoul 151742, South Korea

[3] Harvard Univ, Sch Med, Inst Chem & Cell Biol, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

CANCER LETTERS | 2000年 / 148卷 / 01期

关键词：

p27(Kip1); retinoblastoma protein; apoptosis;

D O I：

10.1016/S0304-3835(99)00319-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

p27(Kip1), a cyclin-dependent kinase (CDK) inhibitor, plays a critical role in cell cycle regulation. Expression of p27(Kip1) is shown to increase during apoptosis in mammalian cells. Here, to directly address the role of p27(KiP1) in apoptosis, p27(Kip1) is overexpressed in human SK-Hep1 hepatoma cells. This leads to apoptotic cell death and this reduces protein, but not mRNA, levels of the retinoblastoma (Rb). Consistently, accumulation of Rb protein blocks p27(Kip1)-mediated apoptosis. These studies demonstrate an involvement of Rb in the apoptotic cell death which is induced by overexpression of p27(Kip1). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：105 / 110

页数：6

共 32 条

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