MEDICAL PROGRESS Alcoholic Hepatitis

被引：674

作者：

Lucey, Michael R. ^{[1
]}

Mathurin, Philippe ^{[2
]}

Morgan, Timothy R. ^{[3
,4
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Sect Gastroenterol & Hepatol, Madison, WI USA

[2] Univ Lille 2, INSERM, Unite 795, Serv Malad Appareil Digestif,Hop Claude Huriez, Lille, France

[3] Vet Affairs Long Beach Healthcare Syst, Gastroenterol Sect, Long Beach, CA USA

[4] Univ Calif Irvine, Div Gastroenterol, Irvine, CA 92717 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 26期

关键词：

TUMOR-NECROSIS-FACTOR; INDUCED LIVER-INJURY; PLACEBO-CONTROLLED TRIAL; PROTEIN-CALORIE MALNUTRITION; TYPE-1; HEPATORENAL-SYNDROME; INDUCED FATTY LIVER; SHORT-TERM SURVIVAL; HEP G2 CELLS; DOUBLE-BLIND; FACTOR-ALPHA;

D O I：

10.1056/NEJMra0805786

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The association between alcohol intake and alcoholic liver disease has been well documented, although cirrhosis of the liver develops in only a small proportion of heavy drinkers. This review focuses on alcoholic hepatitis, a treatable form of alcoholic liver disease. Since up to 40% of patients with severe alcoholic hepatitis die within 6 months after the onset of the clinical syndrome, appropriate diagnosis and treatment are essential. Copyright © 2009 Massachusetts Medical Society. All rights reserved.

引用

页码：2758 / 2769

页数：12

共 99 条

[1] INACTIVATION OF KUPFFER CELLS PREVENTS EARLY ALCOHOL-INDUCED LIVER-INJURY [J].

ADACHI, Y ;

BRADFORD, BU ;

GAO, WS ;

BOJES, HK ;

THURMAN, RG .

HEPATOLOGY, 1994, 20 (02) :453-460

[2] ANTIBIOTICS PREVENT LIVER-INJURY IN RATS FOLLOWING LONG-TERM EXPOSURE TO ETHANOL [J].

ADACHI, Y ;

MOORE, LE ;

BRADFORD, BU ;

GAO, WS ;

THURMAN, RG .

GASTROENTEROLOGY, 1995, 108 (01) :218-224

[3] Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study [J].

Addolorato, Giovanni ;

Leggio, Lorenzo ;

Ferrulli, Anna ;

Cardone, Silvia ;

Vonghia, Luisa ;

Mirijello, Antonio ;

Abenavoli, Ludovico ;

D'Angelo, Cristina ;

Caputo, Fabio ;

Zambon, Antonella ;

Haber, Paul S. ;

Gasbarrini, Giovanni .

LANCET, 2007, 370 (9603) :1915-1922

[4] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[5] Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial [J].

Akriviadis, E ;

Botla, R ;

Briggs, W ;

Han, S ;

Reynolds, T ;

Shakil, O .

GASTROENTEROLOGY, 2000, 119 (06) :1637-1648

[6]

ALEXANDER JF, 1971, AM J GASTROENTEROL, V56, P515

[7] Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide [J].

Angeli, P ;

Volpin, R ;

Gerunda, G ;

Craighero, R ;

Rone, P ;

Merenda, R ;

Amodio, P ;

Sticca, A ;

Caregaro, L ;

Maffei-Faccioli, A ;

Gatta, A .

HEPATOLOGY, 1999, 29 (06) :1690-1697

[8] Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes [J].

Bailey, SM ;

Cunningham, CC .

HEPATOLOGY, 1998, 28 (05) :1318-1326

[9] Mechanisms of disease - Nuclear factor-kappa b - A pivotal transcription factor in chronic inflammatory diseases [J].

Barnes, PJ ;

Larin, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (15) :1066-1071

[10] Applications of Dietary Reference Intakes in dietary assessment and planning [J].

Barr, Susan I. .

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2006, 31 (01) :66-73

← 1 2 3 4 5 6 7 8 9 10 →