Genetics for targeting disease prevention: diabetes

被引：8

作者：

Newell, AM ^{[1
]}

机构：

[1] Oregon State Genet Program, Oregon Dept Human Serv, Portland, OR 97232 USA

来源：

PRIMARY CARE | 2004年 / 31卷 / 03期

关键词：

D O I：

10.1016/j.pop.2004.04.002

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This article provides an overview of current thinking regarding genetics and diabetes (type 1, type 2, and gestational diabetes mellitus), including a selective look at a few implicated gene variants. This article explores how this information might be applied in current and future clinical practice to (1) predict who is at risk for diabetes and its complications, (2) identify and intervene to prevent or delay the development of diabetes in persons at risk, (3) identify patients with diabetes in an early stage and intervene to prevent later complications, and (4) individualize therapy for patients with diabetes to improve outcomes. The article concludes with some general thoughts about genetics and diabetes prevention in the future.

引用

页码：743 / +

页数：25

共 125 条

[1] Family history-taking in community family practice: Implications for genetic screening [J].

Acheson, LS ;

Wiesner, GL ;

Zyzanski, SJ ;

Goodwin, MA ;

Stange, KC .

GENETICS IN MEDICINE, 2000, 2 (03) :180-185

[2] Environmental factors in the etiology of type 1 diabetes [J].

Åkerblom, HK ;

Vaarala, O ;

Hyöty, H ;

Ilonen, J ;

Knip, M .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 115 (01) :18-29

[3] Family history and risk of insulin-dependent diabetes mellitus: a population-based case-control study [J].

Altobelli, E ;

Chiarelli, F ;

Valenti, M ;

Verrotti, A ;

Blasetti, A ;

Di Orio, F .

ACTA DIABETOLOGICA, 1998, 35 (01) :57-60

[4] The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].

Altshuler, D ;

Hirschhorn, JN ;

Klannemark, M ;

Lindgren, CM ;

Vohl, MC ;

Nemesh, J ;

Lane, CR ;

Schaffner, SF ;

Bolk, S ;

Brewer, C ;

Tuomi, T ;

Gaudet, D ;

Hudson, TJ ;

Daly, M ;

Groop, L ;

Lander, ES .

NATURE GENETICS, 2000, 26 (01) :76-80

[5]

American Diabetes Association, 2003, DIABETES CARE S1, V26, pS140

[6]

American Diabetes Association, 2002, DIABETES CARE S1, V25, pS94, DOI [DOI 10.2337/DIACARE.25.2007.S94), 10.2337/diacare.25.2007.S94, DOI 10.2337/DIACARE.25.2007.S94]

[7] Evidence for genetic epistasis in human insulin resistance:: the combined effect of PC-1 (K121Q) and PPARγ2 (P12A) polymorphisms [J].

Baratta, R ;

Di Paola, R ;

Spampinato, D ;

Fini, G ;

Marucci, A ;

Coco, A ;

Vigneri, R ;

Frittitta, L ;

Trischitta, V .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2003, 81 (11) :718-723

[8] Early diagnosis of gestational diabetes mellitus and prevention of diabetes-related complications [J].

Bartha, JL ;

Martinez-Del-Fresno, P ;

Comino-Delgado, R .

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2003, 109 (01) :41-44

[9]

BATCHELDER T, 2000, TOWNSEND LETTER DOCT, V180

[10] What does "a gene for heart disease" mean? A focus group study of public understandings of genetic risk factors [J].

Bates, BR ;

Templeton, A ;

Achter, PJ ;

Harris, TM ;

Condit, CM .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2003, 119A (02) :156-161

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