Solvent-free indoles addition to carbonyl compounds promoted by CeCl3•7H2O-NaI-SiO2:: An efficient method for the synthesis of streptindole

被引：76

作者：

Bartoli, G

Bosco, M

Foglia, G

Giuliani, A

Marcantoni, E

Sambri, L

机构：

[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, MC, Italy

[2] Univ Bologna, Dipartimento Chim Organ A Mangini, I-40136 Bologna, Italy

来源：

SYNTHESIS-STUTTGART | 2004年 / 06期

基金：

匈牙利科学研究基金会;

关键词：

addition reactions; carbonyl complexes; indoles; lanthanides; Lewis acids; natural products;

D O I：

10.1055/s-2004-815967

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient electrophilic substitution reactions of indoles with various carbonyl compounds proceed easily in solvent-free conditions using CeCl3-7H(2)O-NaI-SiO2 system promoter, to afford the corresponding bis(1H-indol-3-yl)alkanes in high yields. The synthetic value of the present procedure is demonstated by the synthesis of streptindole (9), human intestinal bacteria metabolite.

引用

页码：895 / 900

页数：6

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