One-year Weight Losses in the Look AHEAD Study: Factors Associated With Success

被引:389
作者
Wadden, Thomas A. [1 ]
West, Delia S. [2 ]
Neiberg, Rebecca H. [3 ]
Wing, Rena R. [4 ,5 ]
Ryan, Donna H. [6 ]
Johnson, Karen C. [7 ]
Foreyt, John P. [8 ]
Hill, James O. [9 ]
Trence, Dace L. [10 ,11 ]
Vitolins, Mara Z.
机构
[1] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
[2] Univ Arkansas Med Sci, Fay W Boozman Coll Publ Hlth, Dept Hlth Behav & Hlth Educ, Little Rock, AR 72205 USA
[3] Wake Forest Univ, Dept Biostat Sci, Winston Salem, NC 27109 USA
[4] Miriam Hosp, Providence, RI 02906 USA
[5] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA
[6] Pennington Biomed Res Ctr, Dept Clin Res, Baton Rouge, LA USA
[7] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Memphis, TN 38163 USA
[8] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[9] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA
[10] Univ Washington, Dept Endocrinol, Washington, DC USA
[11] VA Puget Sound Hlth Care Syst, Washington, DC USA
[12] Wake Forest Univ, Dept Epidemiol & Prevent, Winston Salem, NC 27109 USA
基金
美国国家卫生研究院;
关键词
RESTING ENERGY-EXPENDITURE; TERM DIETARY INTERVENTION; AFRICAN-AMERICAN; PHYSICAL-ACTIVITY; CONTROL PROGRAM; ACTIVITY GOALS; WHITE WOMEN; OBESE WOMEN; MAINTENANCE; OVERWEIGHT;
D O I
10.1038/oby.2008.637
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This report provides a further analysis of the first year weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with success. Participants were a total of 5,145 men and women with type 2 diabetes who were recruited at 16 sites and randomly assigned to an intensive lifestyle intervention (ILI) or a control condition, Diabetes Support and Education (DSE). During year 1, participants in ILI received comprehensive diet and physical activity counseling in a total of 42 group and individual sessions, compared with three educational sessions for DSE participants. As reported previously, at the end of the year, ILI participants lost 8.6% of initial weight, compared to 0.7% for DSE (P < 0.001). Within the ILI group, all racial/ethnic groups achieved clinically significant weight losses (>5.5%), although there were significant differences among groups. For the year, ILI participants attended an average of 35.4 treatment sessions and reported exercising a mean of 136.6 min/week and consuming a total of 360.9 meal replacement products. Greater self-reported physical activity was the strongest correlate of weight loss, followed by treatment attendance and consumption of meal replacements. The use of orlistat, during the second half of the year, increased weight loss only marginally in those ILI participants who had lost <5% of initial weight during the first 6 months and chose to take the medication thereafter as a toolbox option. The lifestyle intervention was clinically effective in all subsets of an ethnically and demographically diverse population.
引用
收藏
页码:713 / 722
页数:10
相关论文
共 39 条
  • [1] [Anonymous], 2006, Diab Vasc Dis Res
  • [2] Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes
    Brancati, F
    Charleston, J
    Cheskin, L
    Clark, J
    DiGregorio-Celnik, D
    Friedman-Donze, L
    Rubin, R
    Stewart, K
    Bray, GA
    DeLee, DG
    Boss, KR
    Greenway, FL
    Lovejoy, JC
    Ryan, DH
    Williamson, DA
    West, DS
    DiLillo, V
    Raczynski, JM
    Lewis, CE
    Oberman, A
    Thomas, S
    Nathan, DM
    Horton, ES
    Turgeon, H
    Jackson, SD
    Blackburn, GL
    Delahanty, L
    Steiner, B
    Cagliero, E
    Mantzoros, C
    Hill, JO
    Phillipp, J
    Hamman, RF
    Schwartz, R
    Regensteiner, J
    Van Dorsten, B
    McDermott, MT
    Dills, DG
    Foreyt, JP
    Reeves, RS
    Pownell, HJ
    Balasubramanyam, A
    Jones, PH
    Saad, MF
    Jinagouda, S
    Chiu, K
    Morales, L
    Ghazarian, S
    Navarrete, G
    Iqbal, N
    [J]. CONTROLLED CLINICAL TRIALS, 2003, 24 (05): : 610 - 628
  • [3] Insulin treatment and the problem of weight gain in type 2 diabetes
    Carver, Catherine
    [J]. DIABETES EDUCATOR, 2006, 32 (06) : 910 - 917
  • [4] Ditschuneit HH, 1999, AM J CLIN NUTR, V69, P198
  • [5] DPP Res Grp, 2002, DIABETES CARE, V25, P2165
  • [6] Espeland M, 2007, DIABETES CARE, V30, P1374
  • [7] Metabolic and weight loss effects of long-term dietary intervention in obese patients: Four-year results
    Flechtner-Mors, M
    Ditschuneit, HH
    Johnson, TD
    Suchard, MA
    Adler, G
    [J]. OBESITY RESEARCH, 2000, 8 (05): : 399 - 402
  • [8] Foster GD, 1999, AM J CLIN NUTR, V69, P13
  • [9] At last, a weight neutral insulin?
    Fritsche, A
    Häring, H
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 (Suppl 2) : S41 - S46
  • [10] Gregg E. W., 2002, Handbook of obesity treatment, P125