One tissue, two fates: Molecular genetic events that underlie testis versus ovary development

被引：397

作者：

Brennan, J

Capel, B ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 07期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1038/nrg1381

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

The pivotal point of vertebrate sex determination is the development of the gonad into a testis or ovary, which governs phenotypic sex through the production of hormones. The identification of Sry, the genetic switch that controls testis development in mammals, fuelled the race for the discovery of downstream pathways. Comparative analyses of XY versus XX gonadogenesis in both mouse and human genetic mutants have uncovered a burgeoning network of intra- and extra-cellular pathways. Here, we review the old and new players that are involved in the initial steps of testis and ovary development.

引用

页码：509 / 521

页数：13

共 135 条

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Adams IR, 2002, DEVELOPMENT, V129, P1155

[2]

Albrecht KH, 2003, GENETICS, V164, P277

[3]

Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor [J].