Disabling repetitive behaviors in Parkinson's disease

被引:100
作者
Kurlan, R [1 ]
机构
[1] Univ Rochester, Sch Med, Dept Neurol, Rochester, NY 14642 USA
关键词
compulsions; Parkinson's disease; gambling; punding;
D O I
10.1002/mds.10625
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We report on 6 patients with Parkinson's disease who developed severe repetitive behavior, 2 with pathological gambling and 4 with cleaning, rearranging, and ordering rituals. The onset of repetitive behaviors was not associated with changes in antiparkinsonian medications, the behavior did not improve after reductions in dopaminergic therapy, and thus they seem to be part of the underlying illness. The disabling cleaning/rearranging/ordering behaviors had associated features of hypomania, occurred exclusively during motor on periods, and often occurred nocturnally. The repetitive behavior responded poorly to serotonin reuptake inhibitors. Certain atypical antipsychotics may be of benefit. (C) 2004 Movement Disorder Society.
引用
收藏
页码:433 / 437
页数:5
相关论文
共 30 条
[1]   Obsessive-compulsive symptoms in Parkinson's disease [J].
Alegret, M ;
Junqué, C ;
Valldeoriola, F ;
Vendrell, P ;
Martí, MJ ;
Tolosa, E .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2001, 70 (03) :394-396
[2]  
American Psychiatric Association, 2000, DIAGN STAT MAN PSYCH
[3]  
BAXTER L, 1998, NEUROBIOLOGY MENTAL, P530
[4]  
Eapen V, 1997, AM J MED GENET, V74, P432, DOI 10.1002/(SICI)1096-8628(19970725)74:4<432::AID-AJMG15>3.0.CO
[5]  
2-J
[6]  
Fernandez HH, 1999, MOVEMENT DISORD, V14, P836, DOI 10.1002/1531-8257(199909)14:5<836::AID-MDS1018>3.0.CO
[7]  
2-0
[8]   FUNDING ON LEVODOPA [J].
FRIEDMAN, JH .
BIOLOGICAL PSYCHIATRY, 1994, 36 (05) :350-351
[9]  
GEORGE MS, 1993, AM J PSYCHIAT, V150, P93
[10]   Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies [J].
Giovannoni, G ;
O'Sullivan, JD ;
Turner, K ;
Manson, AJ ;
Lees, AJL .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2000, 68 (04) :423-428