Hypocretin (orexin) deficiency in human narcolepsy

被引：1298

作者：

Nishino, S

Ripley, B

Overeem, S

Lammers, GJ

Mignot, E ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat, Ctr Narcolepsy, Stanford, CA 94305 USA

[2] Leiden Univ, Med Ctr, Dept Neurol & Clin Neurophysiol, NL-2300 RC Leiden, Netherlands

来源：

LANCET | 2000年 / 355卷 / 9197期

关键词：

D O I：

10.1016/S0140-6736(99)05582-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.

引用

页码：39 / 40

页数：2

共 5 条

[1] Narcolepsy in orexin knockout mice:: Molecular genetics of sleep regulation [J].

Chemelli, RM ;

Willie, JT ;

Sinton, CM ;

Elmquist, JK ;

Scammell, T ;

Lee, C ;

Richardson, JA ;

Williams, SC ;

Xiong, YM ;

Kisanuki, Y ;

Fitch, TE ;

Nakazato, M ;

Hammer, RE ;

Saper, CB ;

Yanagisawa, M .

CELL, 1999, 98 (04) :437-451

[2] The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene [J].

Lin, L ;

Faraco, J ;

Li, R ;

Kadotani, H ;

Rogers, W ;

Lin, XY ;

Qiu, XH ;

de Jong, PJ ;

Nishino, S ;

Mignot, E .

CELL, 1999, 98 (03) :365-376

[3] Genetic and familial aspects of narcolepsy [J].

Mignot, E .

NEUROLOGY, 1998, 50 (02) :S16-S22

[4] Pharmacological aspects of human and canine narcolepsy [J].

Nishino, S ;

Mignot, E .

PROGRESS IN NEUROBIOLOGY, 1997, 52 (01) :27-78

[5]

Peyron C, 1998, J NEUROSCI, V18, P9996

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