Extrusion of penem antibiotics by multicomponent efflux systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa

被引：44

作者：

Okamoto, K ^{[1
]}

Gotoh, N ^{[1
]}

Nishino, T ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Microbiol, Kyoto 6078414, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2696-2699.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC P-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each system in an AmpG and MexAB-OprM-deficient background and found that MexAB-OprM is the most important among the three efflux systems for extrusion of penems from the cell interior.

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页码：2696 / 2699

页数：4

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