Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

被引：389

作者：

Baumjohann, Dirk ^{[1
,2
,3
]}

Preite, Silvia ^{[1
]}

Reboldi, Andrea ^{[1
]}

Ronchi, Francesca ^{[1
]}

Ansel, K. Mark ^{[2
,3
]}

Lanzavecchia, Antonio ^{[1
]}

Sallusto, Federica ^{[1
]}

机构：

[1] Inst Res Biomed, CH-6500 Bellinzona, Switzerland

[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Sandler Asthma Basic Res Ctr, San Francisco, CA 94143 USA

来源：

IMMUNITY | 2013年 / 38卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

CXC CHEMOKINE RECEPTOR-5; IN-VIVO DEPLETION; DENDRITIC CELLS; IMMUNE-RESPONSES; DIFFERENTIATION; EXPRESSION; BCL6; GENERATION; DYNAMICS; MICE;

D O I：

10.1016/j.immuni.2012.11.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T follicular helper (Tfh) cells provide help to B cells and are crucial for establishment of germinal center (GC) reactions, including production of high-affinity antibodies and generation of memory B cells and long-lived plasma cells. Here we report that the magnitude of the Tfh cell response was dictated by the amount of antigen and directly correlated with the magnitude of the GC B cell response. In addition, maintenance of the Tfh cell phenotype required sustained antigenic stimulation by GC B cells. In lymphopenic conditions, a strong and prolonged Tfh cell response led to bystander B cell activation, hyper-gammaglobulinemia, and production of poly-and self-reactive antibodies. These data demonstrate that antigen dose determines the size and duration of the Tfh cell response and GC reaction, highlight the transient nature of the Tfh cell phenotype, and suggest a link between overstimulation of Tfh cells and the development of dysregulated humoral immune responses.

引用

页码：596 / 605

页数：10

共 67 条

[1] T regulatory cells participate in the control of germinal centre reactions [J].