Antibiotic resistance-the need for global solutions

被引：3382

作者：

Laxminarayan, Ramanan ^{[1
,2
,3
]}

Duse, Adriano ^{[4
]}

Wattal, Chand ^{[5
]}

Zaidi, Anita K. M. ^{[6
]}

Wertheim, Heiman F. L. ^{[7
]}

Sumpradit, Nithima ^{[8
]}

Vlieghe, Erika ^{[9
,10
]}

Levy Hara, Gabriel ^{[11
]}

Gould, Ian M. ^{[12
]}

Goossens, Herman ^{[13
]}

Greko, Christina ^{[14
]}

So, Anthony D. ^{[15
]}

Bigdeli, Maryam ^{[16
]}

Tomson, Goeran ^{[17
,18
,19
,20
,21
]}

Woodhouse, Will ^{[15
]}

Ombaka, Eva ^{[22
]}

Peralta, Arturo Quizhpe ^{[23
]}

Qamar, Farah Naz ^{[6
]}

Mir, Fatima ^{[6
]}

Kariuki, Sam ^{[24
]}

Bhutta, Zulfigar A. ^{[6
]}

Coates, Anthony ^{[25
]}

Bergstrom, Richard ^{[26
]}

Wright, Gerard D. ^{[27
,28
]}

Brown, Eric D. ^{[27
,28
]}

Cars, Otto ^{[29
]}

机构：

[1] Ctr Dis Dynam Econ & Policy, Washington, DC USA

[2] Princeton Univ, Princeton, NJ 08544 USA

[3] Publ Hlth Fdn India, New Delhi, India

[4] Univ Witwatersrand, Johannesburg, South Africa

[5] Sir Gangaram Hosp, New Delhi, India

[6] Aga Khan Univ Karachi, Div Women & Child Hlth, Dept Paediat & Child Hlth, Sindh, Pakistan

[7] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Dis, Oxford, England

[8] Minist Publ Hlth, Food & Drug Adm, Int Hlth Policy Program, Nonthaburi, Thailand

[9] Inst Trop Med, B-2000 Antwerp, Belgium

[10] Univ Antwerp Hosp, Antwerp, Belgium

[11] Hosp Carlos G Durand, Infect Dis Unit, Buenos Aires, DF, Argentina

[12] Aberdeen Royal Infirm, Aberdeen, Scotland

[13] Univ Antwerp, VAXINFECTIO, Lab Med Microbiol, B-2020 Antwerp, Belgium

[14] Natl Vet Inst, Dept Anim Hlth & Antimicrobial Strategies, S-75007 Uppsala, Sweden

[15] Duke Univ, Sanford Sch Publ Policy, Durham, NC USA

[16] WHO, Alliance Hlth Policy & Syst Res, CH-1211 Geneva, Switzerland

[17] Karolinska Inst, Dept Learning Sci, Stockholm, Sweden

[18] Karolinska Inst, Dept Informat Sci, Stockholm, Sweden

[19] Karolinska Inst, Dept Management Sci, Stockholm, Sweden

[20] Karolinska Inst, Dept Eth Sci, Stockholm, Sweden

[21] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden

[22] St Johns Univ Tanzania, Sch Pharm, Dodoma, Tanzania

[23] Univ Cuenca, Fac Med Sci, Cuenca, Ecuador

[24] WellcomeTrust Ctr, Kilifi, Kenya

[25] Univ London, Div Clin Sci, London, England

[26] European Assoc Pharmaceut Ind & Assoc, Brussels, Belgium

[27] McMaster Univ, Michael G DeGroote Inst Infect Dis Res, Hamilton, ON L8S 4L8, Canada

[28] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8S 4L8, Canada

[29] Uppsala Univ, Dept Med Sci, ReAct, Uppsala, Sweden

来源：

LANCET INFECTIOUS DISEASES | 2013年 / 13卷 / 12期

关键词：

COMMUNITY CASE-MANAGEMENT; NON-TYPHOIDAL SALMONELLA; CLOSTRIDIUM-DIFFICILE INFECTION; RESPIRATORY-TRACT INFECTIONS; SMALL-MOLECULE INHIBITOR; RESEARCH-AND-DEVELOPMENT; RAPID DIAGNOSTIC-TESTS; INTENSIVE-CARE UNITS; ANTIMICROBIAL RESISTANCE; STAPHYLOCOCCUS-AUREUS;

D O I：

10.1016/S1473-3099(13)70318-9

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

The causes of antibiotic resistance are complex and include human behaviour at many levels of society; the consequences affect everybody in the world. Similarities with climate change are evident. Many efforts have been made to describe the many different facets of antibiotic resistance and the interventions needed to meet the challenge. However, coordinated action is largely absent, especially at the political level, both nationally and internationally. Antibiotics paved the way for unprecedented medical and societal developments, and are today indispensible in all health systems. Achievements in modern medicine, such as major surgery, organ transplantation, treatment of preterm babies, and cancer chemotherapy, which we today take for granted, would not be possible without access to effective treatment for bacterial infections. Within just a few years, we might be faced with dire setbacks, medically, socially, and economically, unless real and unprecedented global coordinated actions are immediately taken. Here, we describe the global situation of antibiotic resistance, its major causes and consequences, and identify key areas in which action is urgently needed.

引用

页码：1057 / 1098

页数：42

共 378 条

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