Trypanocidal activity and redox potential of heterocyclic- and 2-hydroxy-naphthoquinones

被引：132

作者：

Goulart, MOF

Zani, CL

Tonholo, J

Freitas, LR

deAbreu, FC

Oliveira, AB

Raslan, DS

Starling, S

Chiari, E

机构：

[1] FIOCRUZ MS,CPQRR,LAB QUIM PROD NAT,BELO HORIZONT,MG,BRAZIL

[2] UNIV FED MINAS GERAIS,FAC FARM,BELO HORIZONT,MG,BRAZIL

[3] UNIV FED MINAS GERAIS,ICEX,DEPT QUIM,BELO HORIZONT,MG,BRAZIL

[4] UNIV FED MINAS GERAIS,ICB,DEPT PARASITOL,BELO HORIZONT,MG,BRAZIL

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(97)00354-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

With the aim of understanding the influence of redox potentials on the trypanocidal activity, a series of quinones were tested in vitro with trypomastigotes of Trypanosoma cruzi and their first cathodic potentials (Ep(cl)) measured by cyclic voltammetry. All quinones with Ep(cl) > -0.72V were active, while most of those with Ep(cl) < -0.72V were inactive, suggesting a contribution of the easiness of reduction on the biological activity. (C) 1997 Elsevier Science Ltd.

引用

页码：2043 / 2048

页数：6

共 38 条

[1]

AMES J R, 1986, Journal of Free Radicals in Biology and Medicine, V2, P377, DOI 10.1016/S0748-5514(86)80040-X

[2]

[Anonymous], CHEM QUINONOID COMPO

[3]

ASHNAGAR A, 1984, BIOCHIM BIOPHYS ACTA, V801, P351, DOI 10.1016/0304-4165(84)90138-7

[4] SUPEROXIDE ANION PRODUCTION AND TRYPANOCIDAL ACTION OF NAPHTHOQUINONES ON TRYPANOSOMA-CRUZI [J].

BOVERIS, A ;

STOPPANI, AOM ;

DOCAMPO, R ;

CRUZ, FS .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1978, 61 (02) :327-329

[5]

Cancado J.R., 1979, TRYPANOSOMA CRUZI DO, P362

[6]

Castro J A, 1988, Biomed Environ Sci, V1, P19

[7]

Chambers J.Q., 1988, CHEM QUINONOID COMPO, P719

[8]

CHIARI E, 1996, ANTIMICROB AGENTS CH, P613

[9] CYCLOPROPAMITOSENES, NOVEL BIOREDUCTIVE ANTICANCER AGENTS - SYNTHESIS, ELECTROCHEMISTRY, AND BIOLOGICAL-ACTIVITY OF 7-SUBSTITUTED CYCLOPROPAMITOSENES AND RELATED INDOLEQUINONES [J].

COTTERILL, AS ;

MOODY, CJ ;

MORTIMER, RJ ;

NORTON, CL ;

OSULLIVAN, N ;

STEPHENS, MA ;

STRADIOTTO, NR ;

SWANN, E ;

STRATFORD, IJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (22) :3834-3843

[10]

CRASTON JA, 1993, J CHEM SOC P2, P1589

← 1 2 3 4 →