The effect of moderate alcohol consumption on fat distribution and adipocytokines

被引:74
作者
Beulens, Joline W. J.
van Beers, Roderik M.
Stolk, Ronald P.
Schaafsma, Gertjan
Hendriks, Henk F. J.
机构
[1] TNO Qual Life, NL-3700 AJ Zeist, Netherlands
[2] Univ Wageningen & Res Ctr, Wageningen, Netherlands
[3] Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
关键词
ultrasound; adiponectin; resistin; insulin sensitivity; abdominal obesity;
D O I
10.1038/oby.2006.8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To investigate the effect of moderate alcohol consumption on fat distribution, adipose tissue secreted proteins (adiponectin and resistin), and insulin sensitivity in healthy middle-aged men with abdominal obesity. Research Methods and Procedures: Thirty-four healthy men between 35 and 70 years old, with increased waist circumference (>= 94 cm), participated in a randomized, controlled cross-over design trial. They drank 450 mL of red wine (40 grams of alcohol) or 450 mL of de-alcoholized red wine daily during 4 weeks. At the end of each treatment period, fat distribution, adipose tissue proteins, and insulin sensitivity index (ISI) were measured. Results: Subcutaneous and abdominal fat contents and body weight did not change after 4 weeks of moderate alcohol consumption. Liver fat (quip index) was slightly higher after consumption of red wine (6.8 +/- 0.1) as compared with de-alcoholized red wine (6.5 0.1) but not significantly different (p = 0.09). Plasma adiponectin concentration increased (p < 0.01) to 6.0 +/- 0.1 mu g/mL after 28 days of moderate alcohol consumption compared with de-alcoholized red wine (5.5 +/- 0.1 mu g/mL). Serum resistin concentrations and ISI were not affected by alcohol consumption. Percentage changes in serum resistin correlated significantly with changes in ISI (r = -0.69, p < 0.01), whereas this correlation was not present between changes in plasma adiponectin and IST (r = 0.31, p = 0.22). Discussion: Moderate alcohol consumption for 4 weeks is not associated with differences in subcutaneous and abdominal fat contents or body weight. Thus, the 10% increase in adiponectin was not associated with a change in fat distribution or body weight change.
引用
收藏
页码:60 / 66
页数:7
相关论文
共 38 条
[1]   Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].
Arita, Y ;
Kihara, S ;
Ouchi, N ;
Takahashi, M ;
Maeda, K ;
Miyagawa, J ;
Hotta, K ;
Shimomura, I ;
Nakamura, T ;
Miyaoka, K ;
Kuriyama, H ;
Nishida, M ;
Yamashita, S ;
Okubo, K ;
Matsubara, K ;
Muraguchi, M ;
Ohmoto, Y ;
Funahashi, T ;
Matsuzawa, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83
[2]   ALCOHOL HYPOGLYCEMIA .7. FURTHER STUDIES ON REFRACTORINESS OF OBESE SUBJECTS [J].
ARKY, RA ;
ABRAMSON, EA ;
FREINKEL, N .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1968, 17 (11) :977-&
[3]   Changes in glycemia by leptin administration or high-fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis [J].
Asensio, C ;
Cettour-Rose, P ;
Theander-Carrillo, C ;
Rohner-Jeanrenaud, F ;
Muzzin, P .
ENDOCRINOLOGY, 2004, 145 (05) :2206-2213
[4]   Correlation between serum resistin level and adiposity in obese individuals [J].
Azuma, K ;
Katsukawa, F ;
Oguchi, S ;
Murata, M ;
Yamazaki, H ;
Shimada, A ;
Saruta, T .
OBESITY RESEARCH, 2003, 11 (08) :997-1001
[5]   Adiponectin relationship with lipid metabolism is independent of body fat mass:: Evidence from both cross-sectional and intervention studies [J].
Baratta, R ;
Amato, S ;
Degano, C ;
Farina, MG ;
Patanè, G ;
Vigneri, R ;
Frittitta, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2665-2671
[6]   Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors - The insulin resistance and atherosclerosis study [J].
Bell, RA ;
Mayer-Davis, EJ ;
Martin, MA ;
D'Agostino, RB ;
Haffner, SM .
DIABETES CARE, 2000, 23 (11) :1630-1636
[7]  
BELTOWSKI J, 2003, MED SCI MONITOR, V9, P55
[8]   Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1 [J].
Beulens, JWJ ;
Sierksma, A ;
van Tol, A ;
Fournier, N ;
van Gent, T ;
Paul, JL ;
Hendriks, HFJ .
JOURNAL OF LIPID RESEARCH, 2004, 45 (09) :1716-1723
[9]   Endothelial cell fibrinolysis: Transcriptional regulation of fibrinolytic protein gene expression (t-PA, n-PA, and PAI-1) by low alcohol [J].
Booyse, FM ;
Aikens, ML ;
Grenett, HE .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1999, 23 (06) :1119-1124
[10]   Intra-abdominal fat is a major determinant of the national cholesterol education program adult treatment panel III criteria for the metabolic syndrome [J].
Carr, DB ;
Utzschneider, KM ;
Hull, RL ;
Kodama, K ;
Retzlaff, BM ;
Brunzell, JD ;
Shofer, JB ;
Fish, BE ;
Knopp, RH ;
Kahn, SE .
DIABETES, 2004, 53 (08) :2087-2094