RNA chaperones exist and DEAD box proteins get a life

被引:134
作者
Lorsch, JR [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA
关键词
D O I
10.1016/S0092-8674(02)00804-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The RNA chaperone hypothesis suggests the existence of proteins that resolve misfolded RNA structures in vivo. A recent study (Mohr et al., 2002) has found an RNA-dependent ATPase that functions in this manner.
引用
收藏
页码:797 / 800
页数:4
相关论文
共 19 条
[1]  
[Anonymous], 1999, The RNA World
[2]   Assaying RNA chaperone activity in vivo using a novel RNA folding trap [J].
Clodi, E ;
Semrad, K ;
Schroeder, R .
EMBO JOURNAL, 1999, 18 (13) :3776-3782
[3]   ESCHERICHIA-COLI PROTEINS, INCLUDING RIBOSOMAL-PROTEIN S12, FACILITATE IN-VITRO SPLICING OF PHAGE-T4 INTRONS BY ACTING AS RNA CHAPERONES [J].
COETZEE, T ;
HERSCHLAG, D ;
BELFORT, M .
GENES & DEVELOPMENT, 1994, 8 (13) :1575-1588
[4]   MESSENGER-RNA IS EXPECTED TO FORM STABLE SECONDARY STRUCTURES [J].
GRALLA, J ;
DELISI, C .
NATURE, 1974, 248 (5446) :330-332
[5]   Protein folding - Molecular chaperones in the cytosol: from nascent chain to folded protein [J].
Hartl, FU ;
Hayer-Hartl, M .
SCIENCE, 2002, 295 (5561) :1852-1858
[6]   RNA CHAPERONES AND THE RNA FOLDING PROBLEM [J].
HERSCHLAG, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (36) :20871-20874
[7]   AN RNA CHAPERONE ACTIVITY OF NONSPECIFIC RNA-BINDING PROTEINS IN HAMMERHEAD RIBOZYME CATALYSIS [J].
HERSCHLAG, D ;
KHOSLA, M ;
TSUCHIHASHI, Z ;
KARPEL, RL .
EMBO JOURNAL, 1994, 13 (12) :2913-2924
[8]   MECHANISTIC STUDIES OF RIBONUCLEIC-ACID RENATURATION BY A HELIX-DESTABILIZING PROTEIN [J].
KARPEL, RL ;
MILLER, NS ;
FRESCO, JR .
BIOCHEMISTRY, 1982, 21 (09) :2102-2108
[9]   THE NEUROSPORA CYT-18 PROTEIN SUPPRESSES DEFECTS IN THE PHAGE-T4 TD INTRON BY STABILIZING THE CATALYTICALLY ACTIVE STRUCTURE OF THE INTRON CORE [J].
MOHR, G ;
ZHANG, AX ;
GIANELOS, JA ;
BELFORT, M ;
LAMBOWITZ, AM .
CELL, 1992, 69 (03) :483-494
[10]   A TYROSYL-TRANSFER-RNA SYNTHETASE CAN FUNCTION SIMILARLY TO AN RNA STRUCTURE IN THE TETRAHYMENA RIBOZYME [J].
MOHR, G ;
CAPRARA, MG ;
GUO, QB ;
LAMBOWITZ, AM .
NATURE, 1994, 370 (6485) :147-150