Interceptive effect of Lapachol in rats

被引：13

作者：

Guerra, MO

Mazoni, ASB

Brandao, MAF

Peters, VM

机构：

[1] Univ Fed Juiz De Fora, Ctr Reprod Biol, Juiz De Fora, MG, Brazil

[2] Univ Fed Juiz De Fora, Dept Farmaceut, Fac Farm & Bioquim, Juiz De Fora, MG, Brazil

来源：

CONTRACEPTION | 1999年 / 60卷 / 05期

关键词：

Lapachol; rat; embryo toxicity;

D O I：

10.1016/S0010-7824(99)00091-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Lapachol is a naphtoquinone with therapeutic potential against Chagas disease and is also used as an antimalarial agent. To study the reproductive toxicity potential of Lapachol, pregnant Wistar rats were treated with 0.5 mL of distilled water (control group), 0.5 mL of hydroalcoholic solution (vehicle group), or 20 mg of Lapachol in 0.5 mL of hydroalcoholic solution (treated group) by oral gavage from the 8th to the 12th day of pregnancy. The following variables were observed: maternal body weight on days 1, 6, 15, and 21; food intake on days 2, 6, 15, and 21 of pregnancy. The number of live and dead fetuses and the sites of resorptions were counted. The ovaries were weighed and the corpora lutea were counted. Data were analyzed by ANOVA one-way Dunnett test and chi(2) test. Results showed that mothers were uneffected but there was 100% fetal/embryo mortality, indicative of a strong interceptive effect of Lapachol in rats. CONTRACEPTION 1999;60:305-307 (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：305 / 307

页数：3

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