Inorganic delivery vector for intravenous injection

被引：155

作者：

Kwak, SY

Kriven, WM

Wallig, MA

Choy, JH

机构：

[1] Univ Illinois, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Vet Pathobiol, Urbana, IL 61802 USA

[3] Seoul Natl Univ, Sch Chem, Natl Nanohybrid Mat Lab, Seoul 151747, South Korea

来源：

BIOMATERIALS | 2004年 / 25卷 / 28期

关键词：

nanoparticle; drug delivery; SEM; TEM; in vivo testing;

D O I：

10.1016/j.biomaterials.2004.01.056

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Uniform, small-sized (100-200nm), layered double hydroxides (LDH) were prepared by a conventional, wet chemistry method using different aging times of I and 3 days as an inorganic drug or gene delivery carrier. The samples prepared had a hexagonal thin, plate-like shape and TEM/SAD electron microscopy of LDH particles indicated that they were single crystals. In vivo testing of empty LDH administered to adult male Sprague Dawley rats was done to evaluate, the possibility of using LDH as an injectable drug delivery vehicle. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5995 / 6001

页数：7

共 16 条

[1] Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents - I. Intercalation and in vitro release of ibuprofen [J].