Ritonavir boosted indinavir treatment as a simplified maintenance 'mono'-therapy for HIV infection

被引：30

作者：

Kahlert, C ^{[1
]}

Hupfer, M

Wagels, T

Bueche, D

Fierz, W

Walker, UA

Vernazza, PL

机构：

[1] Cantonal Hosp St Gallen, Div Infect Dis, St Gallen, Switzerland

[2] Cantonal Hosp St Gallen, Div Nephrol, St Gallen, Switzerland

[3] Inst Clin Microbiol & Immunol, St Gallen, Switzerland

[4] Univ Hosp, Div Rheumatol, Freiburg, Germany

来源：

AIDS | 2004年 / 18卷 / 06期

关键词：

D O I：

10.1097/00002030-200404090-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Triple combination is currently the fundamental concept for HIV therapy. We evaluated the feasibility of a 48-week maintenance therapy with ritonavir-boosted indinavir in 12 HIV-infected patients. All patients maintained viral suppression (< 50 copies/ml) throughout the study (one drop-out after week 32) and opted to continue on this monotherapy thereafter. At week 48, no changes in fat distribution patterns were detectable using a dual-energy X-ray absorptiometry scan. These results support the further evaluation of mono-maintenance trials.

引用

页码：955 / 957

页数：3

共 7 条

[1] Maintenance antiretroviral therapies in HIV-infected subjects with undetectable plasma HIV RNA after triple-drug therapy [J].

Havlir, DV ;

Marschner, IC ;

Hirsch, MS ;

Collier, AC ;

Tebas, P ;

Bassett, RL ;

Ioannidis, JPA ;

Holohan, MK ;

Leavitt, R ;

Boone, G ;

Richman, DD .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (18) :1261-1268

[2] Practical implications for the interpretation of minimum plasma concentration/inhibitory concentration ratios [J].

Montaner, J ;

Hill, A ;

Acosta, E .

LANCET, 2001, 357 (9266) :1438-1440

[3]

Moyle G, 2001, AIDS Read, V11, P87

[4] Detection of low HIV-1 RNA levels in plasma [J].

Schockmel, GA ;

Yerly, S ;

Perrin, L .

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1997, 14 (02) :179-183

[5] Discrepancies between protease inhibitor concentrations and viral load in reservoirs and sanctuary sites in human immunodeficiency virus-infected patients [J].

Solas, C ;

Lafeuillade, A ;

Halfon, P ;

Chadapaud, S ;

Hittinger, G ;

Lacarelle, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) :238-243

[6] Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir [J].

van Praag, RME ;

Weverling, GJ ;

Portegies, P ;

Jurriaans, S ;

Zhou, XJ ;

Turner-Foisy, ML ;

Sommadossi, JP ;

Burger, DM ;

Lange, JMA ;

Hoetelmans, RMW ;

Prins, JM .

AIDS, 2000, 14 (09) :1187-1194

[7]

Vernazza PL, 2001, REV MED MICROBIOL, V12, P131

← 1 →