Cytochrome c redistribution in apoptosis of guinea pig vestibular hair cells

被引：17

作者：

Nakagawa, T

Yamane, H

机构：

[1] Yodogawa Christians Hosp, Dept Otorhinolaryngol, Osaka 5330032, Japan

[2] Osaka City Univ, Sch Med, Dept Otorhinolaryngol, Osaka 5450051, Japan

来源：

BRAIN RESEARCH | 1999年 / 847卷 / 02期

关键词：

apoptosis; cytochrome c; mitochondria; vestibular hair cell; aminoglycoside;

D O I：

10.1016/S0006-8993(99)02088-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the cellular location of cytockrome c in healthy and in streptomycin-damaged vestibular hair cells by immunohistochemistry. Staining for cytochrome c revealed an immunostain pattern that was consistent with a mitochondrial distribution of this enzyme in healthy hair cells, while in hair cells affected by aminoglycosides, a diffuse distribution in the cytoplasm was found together with apoptotic nuclear morphology. These findings suggest that redistribution of cytochrome c is involved in the pathway of apoptosis in vestibular hair cells induced by aminoglycosides. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：357 / 359

页数：3

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