The genetics and immunobiology of IgA nephropathy

被引：230

作者：

Kiryluk, Krzysztof ^{[1
]}

Novak, Jan ^{[2
]}

机构：

[1] Columbia Univ, Dept Med, Coll Phys & Surg, New York, NY 10032 USA

[2] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 06期

关键词：

GENOME-WIDE ASSOCIATION; GALACTOSE-DEFICIENT IGA1; CIRCULATING IMMUNE-COMPLEXES; COMPLEMENT FACTOR-H; HUMAN SERUM IGA1; LEUKEMIA INHIBITORY FACTOR; O-LINKED OLIGOSACCHARIDES; HINGE REGION; MASS-SPECTROMETRY; MESANGIAL IGA;

D O I：

10.1172/JCI74475

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

IgA nephropathy (IgAN) represents the leading cause of kidney failure among East Asian populations and the most frequent form of primary glomerulonephritis among Europeans. Patients with IgAN develop characteristic IgA1-containing immune complexes that deposit in the glomerular mesangium, producing progressive kidney injury. Recent studies define IgAN as an autoimmune trait of complex architecture with a strong genetic determination. This Review summarizes new insights into the role of the O-glycosylation pathway, anti-glycan immune response, mucosal immunity, antigen processing and presentation, and the alternative complement pathway in the pathogenesis of IgAN.

引用

页码：2325 / 2332

页数：8

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