Deletion polymorphism of Disc1 is common to all 129 mouse substrains:: Implications for gene-targeting studies of brain function

被引：63

作者：

Clapcote, Steven J.

Roder, John C.

机构：

[1] Mt Sinai Hosp, Res Inst, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

来源：

GENETICS | 2006年 / 173卷 / 04期

关键词：

WORKING-MEMORY; SCHIZOPHRENIA; ASSOCIATION; DEFICIENT; STRAIN;

D O I：

10.1534/genetics.106.060749

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.

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页码：2407 / 2410

页数：4

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