Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate

被引：26

作者：

Southgate, G ^{[1
]}

Daya, S ^{[1
]}

机构：

[1] Rhodes Univ, Div Pharmacol, Fac Pharm, Dept Biochem & Microbiol, ZA-6140 Grahamstown, South Africa

来源：

METABOLIC BRAIN DISEASE | 1999年 / 14卷 / 03期

关键词：

quinolinic acid; melatonin; lipid peroxidation; neurotoxicity; free radical;

D O I：

10.1023/A:1020610708637

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The protective effects of melatonin against the neurotoxin, quinolinic acid, were investigated in rat brain homogenate using the thiobarbituric acid assay. Quinolinic acid increased lipid peroxidation in a dose dependent manner. When homogenate was co-treated with melatonin there was a significant decrease in lipid peroxidation. The results of the present report show that melatonin may play a protective role in the brain against the neurohormone quinolinic acid, which has been identified as a causative agent in Huntington's Disease.

引用

页码：165 / 171

页数：7

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