Effect of cell lipid composition on the formation of nonspecific antibiotic resistance in alkanotrophic rhodococci

被引：20

作者：

Kuyukina, MS ^{[1
]}

Ivshina, IB ^{[1
]}

Rychkova, MI ^{[1
]}

Chumakov, OB ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Ecol & Gent Microorganisms, Ural Div, Perm 614600, Russia

来源：

MICROBIOLOGY | 2000年 / 69卷 / 01期

关键词：

Rhodococcus; n-alkanes; antibiotic resistance; total cell lipids; phospholipids; fatty acid composition;

D O I：

10.1007/BF02757257

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antibiotic resistance and lipid composition of rhodococci grown in rich organic media with gaseous or liquid n-alkanes were studied. Hydrocarbon-grown rhodococci exhibited an increased resistance to a wide range of antibiotics (aminoglycosides, linkosamides, macrolides, beta-lactams, and aromatic compounds). The enhanced antibiotic resistance of rhodococci grown on n-alkanes correlated with an increased content of total cell lipids (up to 14-28%) and saturated straight-chain fatty acids (C-16:0, C-18:0, C-21:0) and was accompanied by the appearance of cardiolipin and phosphatidylglycerol in cells. These lipid compounds are supposed to promote the formation of nonspecific antibiotic resistance in rhodococci by decreasing the permeability of their cell envelope to antibiotics.

引用

页码：51 / 57

页数：7

共 21 条

[1]

CHEEMA S, 1986, INDIAN J EXP BIOL, V24, P705

[2]

CHURKINA LN, 1983, ANTIBIOT MED BIOTEK, V28, P489

[3]

DITTMER JC, 1964, J LIPID RES, V5, P126

[4]

IVSHINA I B, 1982, Mikrobiologiya, V51, P477

[5]

Ivshina I. B., 1994, Mikrobiologiya, V63, P118

[6]

Ivshina I.B., 1994, KATALOG SHTAMMOV REG

[7]

IVSHINA IB, 1990, OTD AKAD NAUK SSSR, P92

[8]

IVSHINA IB, 1997, MIKROBIOLOGIYA, V67, P494

[9]

KATES M, 1975, TECHNIQUES LIPDIOLOG

[10]

Koronelli T., 1995, Mikrobiologiya, V64, P769

← 1 2 3 →