AIDS: Decline and fall of immune surveillance?

被引：21

作者：

Feinberg, MB ^{[1
]}

McLean, AR ^{[1
]}

机构：

[1] INST PASTEUR,LAB DYNAM LYMPHOCYTAIRE,F-75724 PARIS 15,FRANCE

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0960-9822(97)70072-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent observations cast doubt on the view that cytotoxic T cells play a key role in keeping HIV-1 infection in check, and that it is the decline in this mechanism of immune surveillance that permits progression to AIDS.

引用

页码：R136 / R140

页数：5

共 10 条

[1] Evolution and plasticity of CTL responses against HIV
Autran, B
Hadida, F
Haas, G
[J]. CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (04) : 546 - 553
[2] WHY CANT CYTOTOXIC T-CELLS HANDLE HIV
BEVAN, MJ
BRACIALE, TJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (13) : 5765 - 5767
[3] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION
HO, DD
NEUMANN, AU
PERELSON, AS
CHEN, W
LEONARD, JM
MARKOWITZ, M
[J]. NATURE, 1995, 373 (6510) : 123 - 126
[4] Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection
Klenerman, P
Phillips, RE
Rinaldo, CR
Wahl, LM
Ogg, G
May, RM
McMichael, AJ
Nowak, MA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (26) : 15323 - 15328
[5] Prognosis in HIV-1 infection predicted by the quantity of virus in plasma
Mellors, JW
Rinaldo, CR
Gupta, P
White, RM
Todd, JA
Kingsley, LA
[J]. SCIENCE, 1996, 272 (5265) : 1167 - 1170
[6] Serum HIV-1 RNA levels and time to development of AIDS in the multicenter hemophilia cohort study
OBrien, TR
Blattner, WA
Waters, D
Eyster, ME
Hilgartner, MW
Cohen, AR
Luban, N
Hatzakis, A
Aledort, LM
Rosenberg, PS
Miley, WJ
Kroner, BL
Goedert, JJ
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (02): : 105 - 110
[7] HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
Perelson, AS
Neumann, AU
Markowitz, M
Leonard, JM
Ho, DD
[J]. SCIENCE, 1996, 271 (5255) : 1582 - 1586
[8] PERELSON AS, 1996, 11 INT C AIDS VANC, P19
[9] Reduction of HIV concentration during acute infection: Independence from a specific immune response
Phillips, AN
[J]. SCIENCE, 1996, 271 (5248) : 497 - 499
[10] Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes
Yang, OO
Kalams, SA
Rosenzweig, M
Trocha, A
Jones, N
Koziel, M
Walker, BD
Johnson, RP
[J]. JOURNAL OF VIROLOGY, 1996, 70 (09) : 5799 - 5806

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