Epigenetic influences on brain development and plasticity

被引：234

作者：

Fagiolini, Michela ^{[2
]}

Jensen, Catherine L. ^{[1
]}

Champagne, Frances A. ^{[1
]}

机构：

[1] Columbia Univ, Dept Psychol, New York, NY 10027 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2009年 / 19卷 / 02期

关键词：

OLIGODENDROCYTE PROGENITOR DIFFERENTIATION; PROTEIN-RESTRICTED DIET; MATERNAL-CARE; VISUAL-CORTEX; GLUCOCORTICOID-RECEPTOR; SYNAPTIC PLASTICITY; POSTTRANSLATIONAL MODIFICATIONS; ENVIRONMENTAL ENRICHMENT; HISTONE MODIFICATIONS; BDNF TRANSCRIPTION;

D O I：

10.1016/j.conb.2009.05.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A fine interplay exists between sensory experience and innate genetic programs leading to the sculpting of neuronal circuits during early brain development. Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and long lasting molecular, cellular and complex behavioral phenotypes acquired during periods of developmental plasticity. Understanding these mechanisms may give insight into the formation of critical periods and provide new strategies for increasing plasticity and adaptive change in adulthood.

引用

收藏

页码：207 / 212

页数：6

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