Delivery of nascent polypeptides to the mitochondrial surface

被引：47

作者：

Beddoe, T ^{[1
]}

Lithgow, T ^{[1
]}

机构：

[1] Univ Melbourne, Russell Grimwade Sch Biochem & Mol Biol, Parkville, Vic 3010, Australia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2002年 / 1592卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

ribosome; polypeptide synthesis; mRNA localisation; molecular chaperone; protein import; mitochondrion;

D O I：

10.1016/S0167-4889(02)00262-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thousands of polypeptides with diverse biochemical properties, some of which are extremely hydrophobic, are targeted from cytoplasmic ribosomes to the surface of mitochondria. Localised synthesis, as well as transient interactions with a wide array of molecular chaperones and other cytoplasmic factors, can promote productive interaction of mitochondrial proteins with the TOM complex to initiate protein import into mitochondria. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：35 / 39

页数：5

相关论文

共 48 条

[1]

ADES IZ, 1980, J BIOL CHEM, V255, P9918

[2] MAS5, A YEAST HOMOLOG OF DNAJ INVOLVED IN MITOCHONDRIAL PROTEIN IMPORT [J].

ATENCIO, DP ;

YAFFE, MP .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (01) :283-291

[3]

Becker J, 1996, MOL CELL BIOL, V16, P4378

[4] INTERACTION OF HSP-70 WITH NEWLY SYNTHESIZED PROTEINS - IMPLICATIONS FOR PROTEIN FOLDING AND ASSEMBLY [J].

BECKMANN, RP ;

MIZZEN, LA ;

WELCH, WJ .

SCIENCE, 1990, 248 (4957) :850-854

[5] A toxic fusion protein accumulating between the mitochondrial membranes inhibits protein assembly in vivo [J].

Beilharz, T ;

Suzuki, CK ;

Lithgow, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (52) :35268-35272

[6] New insights into signal recognition and elongation arrest activities of the signal recognition particle [J].

Bui, N ;

Strub, K .

BIOLOGICAL CHEMISTRY, 1999, 380 (02) :135-145

[7] YDJ1P FACILITATES POLYPEPTIDE TRANSLOCATION ACROSS DIFFERENT INTRACELLULAR MEMBRANES BY A CONSERVED MECHANISM [J].

CAPLAN, AJ ;

CYR, DM ;

DOUGLAS, MG .

CELL, 1992, 71 (07) :1143-1155

[8] Mft52, an acid-bristle protein in the cytosol that delivers precursor proteins to yeast mitochondria [J].

Cartwright, P ;

Beilharz, T ;

Hansen, P ;

Garrett, J ;

Lithgow, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) :5320-5325

[9] A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae [J].

Chávez, S ;

Beilharz, T ;

Rondón, AG ;

Erdjument-Bromage, H ;

Tempst, P ;

Svejstrup, JQ ;

Lithgow, T ;

Aguilera, A .

EMBO JOURNAL, 2000, 19 (21) :5824-5834

[10] LIMITATIONS TO IN-VIVO IMPORT OF HYDROPHOBIC PROTEINS INTO YEAST MITOCHONDRIA - THE CASE OF A CYTOPLASMICALLY SYNTHESIZED APOCYTOCHROME-B [J].

CLAROS, MG ;

PEREA, J ;

SHU, YM ;

SAMATEY, FA ;

POPOT, JL ;

JACQ, C .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 228 (03) :762-771

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