Novel tryptophan dioxygenase inhibitors and combined tryptophan dioxygenase/5-HT reuptake inhibitors

被引：16

作者：

Madge, DJ ^{[1
]}

Hazelwood, R ^{[1
]}

Iyer, R ^{[1
]}

Jones, HT ^{[1
]}

Salter, M ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 07期

关键词：

D O I：

10.1016/0960-894X(96)00124-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tryptophan dioxygenase (TDO) is a liver enzyme that is responsible for the majority of the metabolism of tryptophan. A series of novel 3-(2-pyridylethenyl)indoles are shown to be potent inhibitors of TDO with selected members of the series also having 5-hydroxy tryptamine (5-HT) reuptake inhibitory activity. These compounds are shown to provide significant increases in the levels of tryptophan and 5-HT in the cerebrospinal fluid and are thus of interest for antidepressant therapy. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：857 / 860

页数：4

共 20 条

[1]

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[2]

ASBERG M, 1976, ARCH GEN PSYCHIAT, V33, P93

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