Synthesis of controlled-release products in supercritical medium

被引:87
作者
Guney, O [1 ]
Akgerman, A [1 ]
机构
[1] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA
关键词
D O I
10.1002/aic.690480419
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Controlled-delivery products have recently received considerable attention. They prolong the drug's therapeutic effect, keeping its concentration between the therapeutic and toxicity limit. The final product must be free of residual solvent, even with nontoxic solvents, to provide its constant property, that does not change with natural evaporation of the solvent. A major cost item in the synthesis of controlled-release drugs is to remove this solvent to acceptable limits. To eliminate the production step involving the organic solvent from the overall process, the drug it-as introduced into the polymer matrix using supercritical carbon dioxide (scCO(2)) as the carrier solvent and swelling agent. This study focuses on the impregnation of a biodegradable polymer matrix with 5-fluoro-uracil for chemotherapy and beta-estradiol estrogen hormone therapy. Swelling of the polymer matrix, solubility of drug components in scCO(2) and the adsorption isotherm/partition coefficients in the presence of scCO(2) were studied. To investigate the single-component supercritical adsorptive synthesis of controlled-delivery products, accurate experimental techniques to measure drug-component solubilities in supercritical fluids and adsorption isotherms in the presence Of supercritical fluids were developed. Solubility, data of these drugs in scCO(2) at 35 - 55degreesC and 101 - 220-bar were reported. The adsorption equilibrium constants/partition coefficients were presented for these drug components on poly-dl-lactide-co-glycolide (PLGA) at the same conditions. To understand the effect of operating variables on the total drug loading and to predict the drug-loading breakthroughs, a flow over a flat plate model was developed that accounts for the polymer swelling, the partitioning of the drug component between the supercritical and polymer phases, and the polymer diffusivity. Experimental isotherm data with and without the polymer were incorporated into the model to isolate the system response from the polymer response to determine impregnation efficiencies.
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页码:856 / 866
页数:11
相关论文
共 20 条
[1]  
ALESSI P, 1998, P 5 M SUP FLUIDS NIC, V1, P373
[2]   MASS-TRANSPORT WITH RELAXATION IN POLYMERS [J].
CAMERARODA, G ;
SARTI, GC .
AICHE JOURNAL, 1990, 36 (06) :851-860
[3]   APPLICATION OF SUPERCRITICAL FLUIDS FOR THE PRODUCTION OF SUSTAINED DELIVERY DEVICES [J].
DEBENEDETTI, PG ;
TOM, JW ;
YEO, SD ;
LIM, GB .
JOURNAL OF CONTROLLED RELEASE, 1993, 24 (1-3) :27-44
[4]   Pressure to change - Supercritical carbon dioxide to toughen common materials [J].
Gibbs, WW .
SCIENTIFIC AMERICAN, 1996, 275 (05) :40-41
[5]   Solubilities of 5-fluorouracil and ß-estradiol in supercritical carbon dioxide [J].
Guney, O ;
Akgerman, A .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2000, 45 (06) :1049-1052
[6]   In situ spectroscopy of polymers subjected to supercritical CO2: Plasticization and dye impregnation [J].
Kazarian, SG ;
Brantley, NH ;
West, BL ;
Vincent, MF ;
Eckert, CA .
APPLIED SPECTROSCOPY, 1997, 51 (04) :491-494
[7]  
KIKIC I, 1998, P INT NATO ASI M KEM
[8]   FRACTIONATION OF POLYMERS WITH SUPERCRITICAL FLUIDS [J].
KUMAR, SK ;
SUTER, UW ;
REID, RC .
FLUID PHASE EQUILIBRIA, 1986, 29 :373-382
[9]  
Leong K.W., 1988, ADV DRUG DELIVER REV, V1, P199
[10]  
McHugh M.A., 1986, SUPERCRITICAL FLUID