Electrospun bioscaffolds that mimic the topology of extracellular matrix

被引：183

作者：

Han, Dong ^{[1
]}

Gouma, Pelagia-Irene ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Mat Sci & Engn, Stony Brook, NY 11794 USA

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2006年 / 2卷 / 01期

关键词：

3D architecture; Artificial scaffold; Cell differentiation; Electrospinning; Tissue engineering;

D O I：

10.1016/j.nano.2006.01.002

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 [材料科学与工程]; 080502 [材料学];

摘要：

Extracellular matrix (ECM) is a natural scaffold for cell, tissue, and organ growth. Its topology plays an important role in cell differentiation. There is a design challenge to fabricate biomaterials that mimic ECM's three-dimensional (3D) structures with defined shapes and complex porous architecture. The urinary bladder matrix (UBM) is used in this work as the model system of the ECM architecture. Cellulose acetate (CA) is the biomaterial of choice for building the UBM-mimicking scaffolds. Electrospinning is the fabrication method used to form complex, porous, 3D structures with specific design, in a single-step process. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：37 / 41

页数：5

共 21 条

[1]

Badylak S. F., 2004, Clinical Techniques in Equine Practice, V3, P173, DOI 10.1053/j.ctep.2004.08.002

[2]

The extracellular matrix as a scaffold for tissue reconstruction [J].

Badylak, SE .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2002, 13 (05) :377-383

[3]

Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: Hepatocytes cultured in a sandwich configuration [J].

Berthiaume, F ;

Moghe, PV ;

Toner, M ;

Yarmush, ML .

FASEB JOURNAL, 1996, 10 (13) :1471-1484

[4]

The use of small intestinal submucosa as an off-the-shelf urethral sling material for pediatric urinary incontinence [J].

Colvert, JR ;

Kropp, BP ;

Cheng, EY ;

Pope, JC ;

Brock, JW ;

Adams, MC ;

Austin, P ;

Furness, PD ;

Koyle, MA .

JOURNAL OF UROLOGY, 2002, 168 (04) :1872-1875

[5]

Cooper GM, 1997, CELL MOL APPROACH, P1

[6]

Electrospinning of polyurethane fibers [J].

Demir, MM ;

Yilgor, I ;

Yilgor, E ;

Erman, B .

POLYMER, 2002, 43 (11) :3303-3309

[7]

DOSHI J, 1995, J ELECTROSTAT, V35, P151, DOI 10.1016/0304-3886(95)00041-8

[8]

Functional cardiac cell constructs on cellulose-based scaffolding [J].

Entcheva, E ;

Bien, H ;

Yin, LH ;

Chung, CY ;

Farrell, M ;

Kostov, Y .

BIOMATERIALS, 2004, 25 (26) :5753-5762

[9]

Beaded nanofibers formed during electrospinning [J].

Fong, H ;

Chun, I ;

Reneker, DH .

POLYMER, 1999, 40 (16) :4585-4592

[10]

Emerging design principles in Biomaterials and scaffolds for tissue engineering [J].

Griffith, LG .

REPARATIVE MEDICINE: GROWING TISSUES AND ORGANS, 2002, 961 :83-95

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