Alginate drug delivery systems: application in context of pharmaceutical and biomedical research

被引：234

作者：

Jain, Dharmendra ^{[1
]}

Bar-Shalom, Daniel ^{[2
]}

机构：

[1] Dr HS Gour Viswavidyalaya Univ, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, India

[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Copenhagen O, Denmark

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2014年 / 40卷 / 12期

关键词：

Beads; floating systems; membranes; microspheres; nanoparticles; sodium alginate; SODIUM ALGINATE; CONTROLLED-RELEASE; SUSTAINED-RELEASE; GASTROESOPHAGEAL-REFLUX; ENTRAPMENT EFFICIENCY; PROLONGED-RELEASE; INTERNAL GELATION; GEL BEADS; MATRIX; PH;

D O I：

10.3109/03639045.2014.917657

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Alginates are natural polymers widely used in the food industry because of their biocompatible, biodegradable character, nontoxicity and easy availability. The bioadhesive character of alginates makes them useful in the pharmaceutical industry as well. The application areas of sodium alginate-based drug delivery systems are many and these systems can be formulated as gels, matrices, membranes, nanospheres, microspheres, etc. Worldwide researchers are exploring possible applications of alginates as coating material, preparation of controlled-release drug delivery systems such as microspheres, beads, pellets, gels, fibers, membranes, etc. In the present review, such applications of alginates are discussed.

引用

页码：1576 / 1584

页数：9

共 81 条

[1]

Evaluation of parameters involved in preparation and release of drug loaded in crosslinked matrices of alginate [J].

Al-Musa, S ;

Abu Fara, D ;

Badwan, AA .

JOURNAL OF CONTROLLED RELEASE, 1999, 57 (03) :223-232

[2]

Preparation and characterization of biodegradable paclitaxel loaded alginate microparticles for pulmonary delivery [J].

Alipour, Shohreh ;

Montaseri, Hashem ;

Tafaghodi, Mohsen .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2010, 81 (02) :521-529

[3]

Swelling behavior of barium ions-crosslinked bipolymeric sodium alginate-carboxymethyl guar gum blend beads [J].

Bajpai, S. K. ;

Saxena, Shilpa Khare ;

Sharma, Shubhra .

REACTIVE & FUNCTIONAL POLYMERS, 2006, 66 (06) :659-666

[4]

Bastos DD, 2009, J MICROENCAPSUL, V26, P97, DOI [10.1080/02652040802175805, 10.1080/02652040802175805 ]

[5]

A NOVEL MULTIPLE-UNIT SUSTAINED-RELEASE INDOMETHACIN HYDROXYPROPYL METHYLCELLULOSE DELIVERY SYSTEM PREPARED BY IONOTROPIC GELATION OF SODIUM ALGINATE AT ELEVATED-TEMPERATURES [J].

BODMEIER, R ;

PAERATAKUL, O .

CARBOHYDRATE POLYMERS, 1991, 16 (04) :399-408

[6]

Mechanistic study on hydration and drug release behavior of sodium alginate compacts [J].

Chan, Lai Wah ;

Ching, Ai Ling ;

Liew, Celine Valeria ;

Heng, Paul Wan Sia .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2007, 33 (06) :667-676

[7]

Mechanisms of external and internal gelation and their impact on the functions of alginate as a coat and delivery system [J].

Chan, LW ;

Lee, HY ;

Heng, PWS .

CARBOHYDRATE POLYMERS, 2006, 63 (02) :176-187

[8]

Liquid phase coating to produce controlled-release alginate microspheres [J].

Chan, LW ;

Liu, XH ;

Heng, PWS .

JOURNAL OF MICROENCAPSULATION, 2005, 22 (08) :891-900

[9]

Preparation of alginate beads for floating drug delivery system:: effects of CO2 gas-forming agents [J].

Choi, BY ;

Park, HJ ;

Hwang, SJ ;

Park, JB .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 239 (1-2) :81-91

[10]

A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye [J].

Cohen, S ;

Lobel, E ;

Trevgoda, A ;

Peled, Y .

JOURNAL OF CONTROLLED RELEASE, 1997, 44 (2-3) :201-208

← 1 2 3 4 5 6 7 8 9 →