Cervical shedding of herpes simplex virus in human immunodeficiency virus-infected women: Effects of hormonal contraception, pregnancy, and vitamin A deficiency

被引:74
作者
Mostad, SB
Kreiss, JK
Ryncarz, AJ
Mandaliya, K
Chohan, B
Ndinya-Achola, J
Bwayo, JJ
Corey, L
机构
[1] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[2] Univ Washington, Dept Med, Seattle, WA 98195 USA
[3] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA
[4] Fred Hutchinson Canc Res Ctr, Program Infect Dis, Seattle, WA 98104 USA
[5] Coast Prov Gen Hosp, Mombassa, Kenya
[6] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya
关键词
D O I
10.1086/315188
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Genital shedding of herpes simplex virus (HSV) results in frequent transmission of infection to sexual partners and neonates, In a cross-sectional study, cervical shedding of HSV DNA was detected in 43 (17%) cervical swab samples from 273 women seropositive for HSV-1, HSV-2, and human immunodeficiency virus type 1 (HIV-1), Cervical shedding of HSV was significantly associated with oral contraception (adjusted odds ratio [aOR], 4.5; 95% confidence interval [CI], 1.7-12.2), use of depo-medroxyprogesterone acetate (aOR, 3.2; 95% CI, 1.3-7.7), and pregnancy (aOR, 7.9; 95% CI, 2.0-31.7). In the subgroup of women who were not pregnant and not using hormonal contraception (n = 178), serum vitamin A was highly predictive of cervical HSV shedding: concentrations indicating severe deficiency, moderate deficiency, low-normal, and high-normal status were associated with 29%, 18%, 8%, and 2% prevalences of cervical HSV shedding, respectively (linear trend, P = .0002), Several factors appear to influence HSV reactivation in HIV-1 seropositive women.
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页码:58 / 63
页数:6
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