Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats

被引：10

作者：

Tanira, MOM

Ali, BH

Bashir, AK

Dhanasekaran, S

Tibiriçá, E

Alves, LM

机构：

[1] Sultan Qaboos Univ, Dept Pharmacol, Coll Med, Muscat 123, Oman

[2] Desert & Marine Environm Res Ctr, Rio De Janeiro, Brazil

[3] FMHS, Rio De Janeiro, Brazil

[4] UAE Univ, Rio De Janeiro, Brazil

[5] FIOCRUZ, Lab Fisiol & Farmacodinam, Inst Oswaldo Cruz, BR-21045900 Rio De Janeiro, Brazil

来源：

PHARMACOLOGICAL RESEARCH | 2000年 / 41卷 / 03期

关键词：

Rhazya stricta; hypotensive; central; pithed; rat; intracerebroventricular (icv);

D O I：

10.1006/phrs.1999.0598

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The hypotensive action of Rhazya stricta lyophilized leaf extract was found to be partly caused by the electrolyte content of the extract, and partly caused by a strongly basic alkaloidal fraction (AF). AF (0.05-1.6 mg animal(-1)) caused a dose-dependent reduction in mean arterial blood pressure (MAP) of urethane-anaesthetized rat preparations. Tn naive pithed rats, AF administration (0.5-2.0 mg animal(-1)) significantly increased MAP. In pithed or spinalized rats made normotensive by noradrenaline infusion, AF (0.25 mg animal(-1)) did not cause any significant changes. Direct intracerebroventricular injection of AF (0.1-0.4 mg) markedly and significantly reduced MAP. It is suggested that the hypotensive action of AF to be mediated by a central mechanism. (C) 2000 Academic Press.

引用

页码：369 / 378

页数：10

共 10 条

[1] CENTRAL-NERVOUS-SYSTEM ACTIVITY OF RHAZYA-STRICTA (DECNE) IN MICE [J].