Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2

被引:58
作者
Brants, JR
Ayoubi, TAY
Chada, K
Marchal, K
Van de Ven, WJM
Petit, MMR
机构
[1] Univ Leuven, Dept Human Genet, Oncol Mol Lab, B-3000 Louvain, Belgium
[2] Flanders Interuniv, Inst Biotechnol, B-3000 Louvain, Belgium
[3] Univ Maastricht, CARIM, NUTRIM, Dept Populat Genet Genom & Bioinformat, NL-6200 MD Maastricht, Netherlands
[4] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem, Piscataway, NJ 08854 USA
[5] Univ Leuven, ESAT, SCD, B-3000 Louvain, Belgium
来源
FEBS LETTERS | 2004年 / 569卷 / 1-3期
关键词
coding region determinant-binding protein; high mobility group A1; insulin-like growth factor II; hnRNP K homology-domain containing protein overexpressed in cancer; p62; VICKZ;
D O I
10.1016/j.febslet.2004.05.075
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2-deficient mouse strains, which display a pygmy-phenotype, as compared to wild-type mice. We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild-type HMGA2 and its tumor-specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
引用
收藏
页码:277 / 283
页数:7
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