Crystal structure and biological activities of water-soluble nickel(II) and copper(II) complexes of a Schiff-base derived from paeonol

被引：38

作者：

Qin, Dong-Dong ^{[1
]}

Yang, Zheng-Yin ^{[1
]}

Qi, Gao-Fei ^{[1
]}

Li, Tian-Rong ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

TRANSITION METAL CHEMISTRY | 2009年 / 34卷 / 05期

基金：

中国国家自然科学基金;

关键词：

DNA-BINDING; ELECTRONIC-PROPERTIES; ACID;

D O I：

10.1007/s11243-009-9222-z

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

Water-soluble Ni(II) and Cu(II) complexes of a flexible Schiff-base ligand have been synthesized, and the Ni(II) complex was characterized by X-ray crystallography. The interactions of the two complexes with calf thymus DNA were investigated by spectroscopic and viscosity measurements in water. The results suggest that the two complexes bind to DNA within the groove. Antioxidant experiments against OHaEuro cent and O (2) (-aEuro cent) show that these two complexes have excellent ability to scavenge O (2) (-aEuro cent) , and the Cu(II) complex exhibits better activity than the Ni(II) complex.

引用

页码：499 / 505

页数：7

共 44 条

[1]

Synthesis and spectroscopic studies on ternary bis-Schiff-base complexes having oxygen and/or nitrogen donors [J].