Pathogenic role of anti-C1q autoantibodies in the development of lupus nephritis - a hypothesis

被引：52

作者：

Flierman, Roelof ^{[1
]}

Daha, Mohamed R. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Nephrol, NL-2333 ZA Leiden, Netherlands

来源：

MOLECULAR IMMUNOLOGY | 2007年 / 44卷 / 1-3期

关键词：

systemic lupus erythematosus; lupus nephritis; anti-C1q autoantibodies; anti-dsDNA autoantibodies; anti-nucleosome autoantibodies; glomerulonephritis; renal disease;

D O I：

10.1016/j.molimm.2006.06.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A substantial proportion of patients with systemic lupus erythematosus (SLE) develop renal inflammatory disease, so-called lupus nephritis (LN). LN is a severe complication of SLE which is strongly associated with the presence of autoantibodies against C1q, the first component of the complement system, and other self-antigens (i.e. against DNA and nucleosomes) as well. In this review, the authors focus on anti-C1q autoantibodies and interpret the available data in order to explain how LN may develop and how anti-C1q autoantibodies contribute to its pathogenesis. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：133 / 138

页数：6

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