Chimerism as a tool to induce clinical transplantation tolerance

被引：36

作者：

Claas, F ^{[1
]}

机构：

[1] Leiden Univ, Ctr Med, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, Netherlands

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.coi.2004.07.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The principle that the induction of (mixed) hematopoietic chimerism can lead to transplantation tolerance to another organ from the same donor has been verified in rodents, in large animals including non-human primates and recently in a selected group of renal transplant recipients. The wide application of this tool depends on the development of more gentle, non-toxic induction protocols and reliable assays with which to detect the establishment of stable donor-specific tolerance.

引用

收藏

页码：578 / 583

页数：6

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