Platelets and inflammation

被引:158
作者
Klinger, MHF
机构
[1] Institute of Anatomy, University of Lübeck, Medical School, D-23538 Lübeck
来源
ANATOMY AND EMBRYOLOGY | 1997年 / 196卷 / 01期
关键词
allergy; alpha-granules; chemokines; infection; inflammatory cells;
D O I
10.1007/s004290050075
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Besides their functions in the haemostatic process and in thrombus formation after an endothelial injury, blood platelets also take part in the processes of inflammation and tissue repair that follows. For this purpose, they closely collaborate with all types of leukocytes. Activated platelets secret chemotactic substances, they facilitate the binding of leukocytes to the endothelium and their subsequent extravasation, and they may influence the inflammatory responses of leukocytes in both stimulating and inhibiting ways. However, platelets themselves also contain an array of potent proinflammatory substances, and therefore they are regarded as mediator and effector cells in inflammation. Their capability to interact with bacteria, parasites, and other foreign materials is possibly a phylogenetic vestige and may explain the existence of IgE-dependent killing mechanisms of platelets. On the other hand, the connection between IgE and platelets, besides the platelet-induced eosinophil infiltration, offers a functional basis for the involvement of platelets in allergic processes, particular in the skin and the airways.
引用
收藏
页码:1 / 11
页数:11
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